At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $142,500 - $228,800 Our diverse ADME team is seeking an upbeat, dynamic scientist interested in the discovery and clinical development of medicines including small molecules, biologics/antibodies, peptides, ADCs, siRNAs, gene therapies, and other complex modalities. You will serve as a technical leader within the department and across portfolio cross-functional teams to deliver novel therapies to patients. This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We support one another through shared-learning and mutual-responsibility for the enterprise of making medicines. Please connect with us if you are a motivated and collaborative scientist looking for an opportunity to innovate at the forefront of novel therapies to improve the lives of patients. Apply today! We want you on our team. **A high-quality candidate will demonstrate the following:** + High learning agility and a keen ability to derive and efficiently test ADME and DMPK hypotheses + Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles across a variety of therapeutic modalities + Understanding of contemporary pharmaceutical regulatory guidance and expectations + Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations + Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics **Lilly-ADME seeks a skilled ADME / DMPK scientist who will:** + Lead and innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly portfolio across modalities including small molecules, biologics/antibodies, peptides, ADCs, siRNAs, gene therapies and other complex modalities + Design and implement hypothesis driven studies to answer ADME, PK/PD and clinical pharmacology questions + Be accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions + Partner with cross-functional colleagues in both Discovery and Development (eg. Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical) to assess drugability and optimize ADME properties to deliver drug candidates to the clinic, as well as to design and support nonclinical and clinical studies supporting global registration packages + Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry understanding to define structure-activity and structure-property-relationships and deliver favorable molecular and experimental design strategies to guide drug delivery and optimization + Engage, innovate, and collaborate with colleagues and interdisciplinary teams + Lead the preparation of regulatory communication and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide + Build and foster relationships through coaching and mentorship with fellow scientists + Possess excellent written and verbal technical communication and the ability to lead, guide and influence teams in decision making **Basic Requirements:** Ph.D. in Biochemistry/Biology/Cell Biology/Pharmacokinetics/Pharmacology or a related scientific field. Entry level to 5 years relevant experience. **Additional Skills/Preferences:** + Experience with PK/PD modeling and/or biodistribution + Experience in drug discovery and development across a variety of therapeutic areas + Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology + Detailed understanding of pharmacokinetics, ADME, drug interactions, and proficiency to communicate theory and concepts clearly + Ability to balance multiple projects and handle competing responsibilities + Demonstrate strong communication skills with the ability to integrate diverse perspectives and to crisply deliver critical messaging + Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community + Experience authoring regulatory and technical reports + Experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab, etc.). Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. \#WeAreLilly