Associate Director Scientist

The Associate Director Scientist is an important member of the Project Team, working under the supervision of a clinical lead/study physician or senior clinical scientist, supporting activities related to the medical scientific aspects of the compound and its development.  The accountabilities are broad, however, the core accountabilities are the medical & scientific support for the development and implementation of early phase AstraZeneca sponsored clinical program strategy, externally sponsored collaborative research program strategy and studies, including clinical science support for initiating clinical trial(s), supporting clinical data review, interpretation of the study results and supporting final recommendations to senior management. As a key member of the Global Project Team, this position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of stakeholders both within and external to AstraZeneca.

The following tasks would be performed under the guidance of the clinical lead, physician or a senior member of the Clinical Science team, with the expectation that over time the AD Scientist would function more independently.

Program Level:

Assists with the clinical input to the clinical development plan at all stages of the program.

Supports the science-to-man sub team (TSST) to integrate the biology, translational and clinical science into the program strategy

Supports in developing recommendation(s) on further development strategies to internal committees

Supports the preparation of clinical and other data for governance and other presentations

Supports the preparation of program level documents such as the investigators brochure and DUSR.

Follows important developments and trends in the medical & scientific literature and disseminates updates to the project team and beyond ensuring all involved parties are aware of key developments and the impact on the strategy, with physician or senior clinical scientist support.

Supports the collaboration with the Lead Bio-scientist and Translational scientist to provide clinical input to the development and review of data for input to the development of pre-CDID compounds

Supports the development and review of content and quality of publications and inputs to development of the publication strategy

Study level (when assigned as clinical science resource for study):

The AD Scientist will support the study lead or in some instances serve as the clinical lead for the study

Supports aspects of the Clinical Development Plan (CDP) and Clinical Study Protocols in keeping with the approved CDP and ensuring linkage of trial data to target product profile

Supports with clinical data review and interpretation at the study and program level with input from the study or program physician

Supports the compilation and interpretation of the data for and from the dose escalation committee/safety review committee, in collaboration with the program physician

Supports the preparation of clinical and other data for governance and other presentations

Supports medical and scientific input to specific studies as required by the program clinical lead/study physician

Supports updates for the protocols, amendments, and other relevant strategic documents. Supports the review of the Clinical Study Report

External:

Supports development of investigator/site relationships to support site selection and study start up activities

Co-leads/supports the development and implementation of the externally sponsored collaborative research (ESCR) strategy for a program. The clinical scientist is the link between the project team and all external clinical research for the program.

Co-leads/Supports investigator and site relationships for clinical proposal reviews, protocol review and approval, scientific oversight and discussions for academic basket/umbrella study and ESCR studies

Identifies and manages risks within the ESCR portfolio, raises quality issues through the appropriate channels, maintains communications with key AstraZeneca stakeholders as required.

Supports the physician/senior clinical scientist in representing the project internally and externally with key external experts. Supports development of alliances as appropriate.

Required Education and Experience

Master of Science, or relevant Pharmacy, Nursing, MSc/MRes degree with 2+ years of Clinical drug development or medical research experience within a pharmaceutical/biotech or academic environment

Or a Relevant Clinical or Biomedical Ph.D

Qualifications, Skills and Experience

Basic knowledge of clinical oncology practice and the science of cancer, with the ability to rapidly acquire knowledge

Experience supporting delivery and influencing at senior leadership levels both internally and externally

Experience in working and leading in matrix teams

Strong collaborative communications skills including the ability to engage with a diverse internal and external client base and manage through conflict

Proven ability in problem solving and issues management that is solution focused

Experience in collaborating externally, influencing delivery and scientific engagement.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we follow the science, driven by curiosity and a commitment to explore new frontiers. Our teams are empowered to push boundaries, transforming molecules into life-changing medicines. With a focus on Oncology, we aim to eliminate cancer as a cause of death. Our collaborative research environment unites academia and industry, expediting breakthroughs in some of the hardest-to-treat cancers. Join us to build a rewarding career dedicated to improving millions of lives. Ready to make a difference? Apply today!

The annual base pay (or hourly rate of compensation) for this position ranges from $138,736 to $208,104. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

27-Feb-2025

Closing Date

02-Apr-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.