Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Arrowhead Pharmaceuticals is seeking an experienced and highly motivated Associate Scientist to join our growing Biology team at our research and development facility in Madison, WI. This role will focus on supporting in vitro, ex vivo, and/or in vivo studies to drive drug discovery and development.

Responsibilities

Support in vitro, ex vivo and/or in vivo studies to facilitate drug discovery and development Perform cell-based functional assays Perform gene expression and functional analysis by various methods Support teams in new target identification and validation Maintain a high level of productivity in the lab and perform critical experiments  Primary Bioassays Responsibilities: Execution of biological assays examining gene and protein expression RNA isolation & qPCR, immunoassays, luminescence-based assays Data analysis Excel and Benchling experience preferred Work with a small team of scientists, while working closely with other research groups and senior managers

Requirements:

Bachelor’s degree in biology or related field, or associate’s degree in related field with at least 1 years of experience in cell biology, molecular biology, immunology, pharmacology, or related field of Biology Strong problem-solving skills Excellent oral and written communication skills Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment

 Preferred:

Industrial (Biotech or Pharma) research experience Experience with methods and technologies involving mammalian cell culture, in vitro cell-based assays, molecular biology including qPCR, immunoassays, and microscopy Knowledge of pulmonary, cardiovascular, CNS or metabolic disease Wisconsin pay range $55,000—$65,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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