Johnson and Johnson Innovative Medicine (JJIM) is recruiting a graduate student for an intern position within the In Silico Discovery group, Spring House, PA. At JJIM, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen JJIM discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, cardiovascular and metabolic diseases, and public health. Please visit https://innovativemedicine.jnj.com/http://www.janssenrnd.com/ (https://innovativemedicine.jnj.com/http://www.janssenrnd.com/) for more information. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer. We are currently seeking an outstanding and motivated individual to work as a summer intern with the In Silico Discovery group located in Spring House, PA. Off-target effects present a significant challenge in the pharmaceutical industry, often resulting in adverse side effects and decreased therapeutic efficacy. This study is designed to evaluate two distinct structure-based drug design (SBDD) methods focused on addressing hERG liabilities within compound series and sub-series across various projects. Through comparative analysis, we can demonstrate the strengths and limitations of each method in mitigating associated side effects. The binding modes identified for a series of compounds could provide insights for modifying functional groups, potentially reducing off-target affinity. By refining these strategies with experimental validation, we aim to enhance the drug design process, leading to safer and more effective therapeutics. Ultimately, the selected SBDD workflow will be integrated with our machine learning models to create a comprehensive in silico strategy. Skills: + Familiarity with protein structures and biochemistry + Comfort working in a Linux-based computing environment throughout the duration of the internship + Excellent oral and written communication skills + An open mind and willingness to learn **Qualifications** Requirement: + Legally/permanently authorized to work in the US with no sponsorship required for employment visa status (e.g. H1-B status) now or in the future. + M.S. or Ph.D. students pursuing studies in computational chemistry, cheminformatics, or a relevant field + Currently enrolled in an accredited college or university + Candidates must be available to work 40 hours/week Permanently authorized to work in the U.S., must not require sponsorship of an employment visa (e.g., H- 1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually requires future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.