About the role:

10x Genomics is seeking a Protein Design Intern for Summer 2025. This intern will explore AI-driven protein design methods to develop and evaluate novel proteins for spatial biology applications. The role will involve computational protein design, expression, bioconjugation, and tissue-based validation, with opportunities to contribute to both applied and exploratory research.

The intern will work closely with computational biology, protein engineering, and assay development teams to assess the feasibility of AI-driven protein engineering for future 10x Genomics platforms. This is an exciting opportunity to work at the forefront of AI-driven protein design, gaining exposure to cutting-edge computational and experimental techniques

This internship provides hands-on experience at the intersection of AI-driven protein design and experimental validation in a cutting-edge biotech environment. Interns will gain valuable industry experience, collaborate with leading scientists, and contribute to next-generation spatial biology innovations.

 

What you will be doing:

 

Computational Protein Design:

Use AI-based tools to design and optimize proteins for specific applications.

Protein Expression & Purification:

Express and purify recombinant proteins using standard molecular biology techniques.

Bioconjugation & Labeling:

Modify proteins for tissue-based validation and imaging experiments.

Tissue Evaluation: 

Test protein function in tissue samples using fluorescence microscopy and other assays.

Data Analysis & Reporting: 

Analyze experimental results, refine designs, and document findings.

Collaboration & Communication:

Work closely with cross-functional teams and present project outcomes.

 

To be successful in this role, you will need:

Currently enrolled in a M.S. or Ph.D. program in Biochemistry, Molecular Biology, Bioengineering, Computational Biology, or a related field. Experience with AI-driven protein design tools (e.g., RFdiffusion, Rosetta, AlphaFold, Foldit, EVOLVEPro) Experience with computational protein design tools (e.g., deep learning-based or traditional modeling software). Hands-on experience with protein expression and purification techniques. Strong programming ability in Python, R, or MATLAB for data analysis.

Nice to Have:

Strong analytical and problem-solving skills. Excellent communication and teamwork abilities. Self-motivated and eager to explore new approaches Familiarity with bioconjugation methods and imaging techniques is a plus

“Regular” US-Based Jobs (Single Region) - Internships:

Below is the base pay range for this position.  The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience.  Unless otherwise required by law, this role is not eligible for 10x’s health benefit program.  During the hiring process, your 10x recruiter can share more information about the Company’s compensation and benefits.

Pay Range$26—$48 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference. 

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.