**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . **Position Summary** The Immunology and Cardiovascular Thematic Research Center (ICV TRC) is focused on discovering and developing novel therapeutics to treat immunological and cardiovascular diseases. The Cardiovascular Discovery group within the ICV-TRC seeks to understand disease pathophysiology to enable target identification that will allow the discovery of novel therapeutics for patients with cardiovascular diseases. BMS seeks a highly motivated, creative, and collaborative Molecular and/or Cellular Biologist to join our Cardiovascular Discovery group. This person will support research efforts to discover and develop novel therapies for the treatment of serious cardiovascular disease, including genetic cardiomyopathies and heart failure. The successful candidate will work collaboratively with teams in Cell Biology, Biochemistry/Biophysics, Lead Discovery and Optimization (LDO) among others to support BMS's Cardiovascular Research and Early Discovery efforts. Research will be aimed at establishment and validation of cellular models for novel therapeutic targets, and development of cellular assays for screening therapeutics. The candidate will be a highly motivated individual with extensive experience in iPSC handling and cardiomyogenic differentiation, molecular and cellular biology techniques, gene expression modulation and cellular assay development. Previous experience with engineered heart tissue (EHT) formation and screening methodologies will be highly desirable. This position provides the exciting opportunity to be a part of and grow with a key discovery function within the CV Discovery group. **Key Responsibilities** + Work independently and collaboratively in cross-functional teams to advance state-of-the-art molecular techniques for disease mechanisms and drug development research. + Demonstrate technical proficiency, scientific creativity, and independent thought in suggesting experimental design and research strategy. + Broad range of molecular and cellular biology methods to interrogate and validate iPSC disease models and novel therapeutic targets/hypotheses. + Support iPSC-CM differentiation and manufacturing towards generating disease models and supporting screening campaigns. + Work closely with our discovery biology and LDO teams to develop and optimize cell-based biological and validation assays. + Support development of EHTs from various iPSC-CM disease lines towards generating of appropriate CV disease models. + Ability to stay current with scientific literature and technologies and interpret literature results in light of new findings. + Prepare reports, publications and present to cross-functional teams and senior management. **Qualifications & Experience** **Basic Qualifications:** + Bachelor, Master's or PhD with 1-2 years of experience working with iPSC differentiation + Must be available to work from January 2025 to June 2025 **Preferred Qualifications:** + Extensive hands-on experience in cell biology and cellular assays including iPSC maintenance and cardiogenic differentiation is required + Documented experience with methodologies for functional assessment of iPSC-CMs (contractility, electrophysiology, metabolic properties, and other) is strongly preferred + Familiarity with development and application of EHTs for CV disease modeling using healthy and mutant iPSC lines is highly desirable + Strong experience with cellular and molecular biology methodologies including cytotoxicity assays, gene expression analysis, RNAi technologies, immunocytochemistry is needed. The starting compensation for this job is a range from $27.00/hour - $43.00/hour. The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final individual compensation is decided commensurate with demonstrated experience and education level. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. **Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. **On-site Protocol** BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. **Company:** Bristol-Myers Squibb **Req Number:** R1585503 **Updated:** 2024-11-13 03:12:21.562 UTC **Location:** Brisbane-CA Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.