Title: Diagnostic Science Manager
Location: Cambridge, UK
Salary: Competitive
Are you an experienced diagnostic scientist with a passion to apply your skills and bring technical expertise and scientific innovation to develop diagnostics for use in a clinical setting? If so, this could be the role for you!
AstraZeneca delivers companion and complementary diagnostic assays that match medicines to those patients who are most likely to benefit from them. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient.
As a Diagnostic Scientist, you will use your knowledge of oncology diagnostic technologies and approaches including for eg. Immunohistochemistry (IHC), multiplex IHC and proteomics, digital pathology to provide scientific and technical expertise to deliver innovative diagnostic approaches to AstraZeneca’s clinical portfolio, through strategic partnerships with leading diagnostic companies and laboratory-based science delivery.
Accountabilities:
Being responsible for the delivery of laboratory- based diagnostic science and innovation projects with a particular focus on multiplex IHC and proteomics, through close collaboration with the cross-functional teams
Building and maintaining a knowledge of current and new technologies in diagnostics for the AZ oncology portfolio, and seeing opportunities for innovation and internal/external collaborations
Developing innovative diagnostic science proposals across core therapeutic areas
Evaluating the performance of novel diagnostics through delivery of diagnostic feasibility studies and laboratory-based science to timelines and budget
Providing scientific and strategic feedback into precision medicine approaches for diagnostic and drug product teams
Ensuring that all activities are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures, including compliant management of Budget, Safety, Health and Environment
Education, Qualifications, Skills and Experience:
Essential:
Masters / PhD or equivalent experience in a relevant subject
Record of delivery in a scientific capability, including peer-reviewed publications
Expertise with IHC and one or more of the following technologies (for example, but not limited to: digital pathology, multiplex proteomics, NGS, PCR & imaging)
Excellent knowledge of current technology trends in oncology diagnostics and precision medicine
Experience of working with external partners or collaborators (ideally academic investigators and diagnostic companies)
Ability to communicate with cross-functional stakeholders for project updates through oral presentations and progress reports
Desirable:
Experience developing tissue-based diagnostic assays in a regulated environment e.g. under In Vitro Diagnostics development standards or within a CAP/CLIA laboratory
Experience of leading projects within a diagnostic or drug development organisation
An understanding of drug and companion diagnostic assay co-development and commercialisation and experience working in early and/or late phase projects
Demonstrable experience of analytical diagnostic assay validation, use in a clinical testing setting and / or delivery of regulatory submission
Good computational and data analysis skills enabling automated/semi-automated analysis of large datasets (e.g. using software and programming languages such as R, Python, knime or equivalent)
Knowledge of requirements related to handling of Human Biological Samples
What is next?
Are you ready to make a difference? Apply today and join us in our mission to improve global public health!
We welcome your applications not later than 28th February 2025.
Where can I find out more?
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
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Date Posted
03-Feb-2025Closing Date
28-Feb-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.