Site Name: Belgium-Rixensart Posted Date: Jan 29 2025 //Field based worker, expected to be on-site// The Nucleic Acid Vaccines Center of Excellence (NAV CoE), a global team within the GSK’s Drugs Substance Vaccine’s Technical Research and Development organization, has as a mission to develop the next generation mRNA Drug Substance vaccine platforms for rapid development of new vaccine candidates. It has branches in Rockville, US (to be moved to Cambridge, US in Q2 2025) and in Rixensart, Belgium. We are looking for a highly motivated Downstream Process Development Principal Scientist to join the mRNA Drug Substance (DS) team and work on delivering new mRNA vaccine candidates from development to the clinical manufacturing stages, a role located in Rixensart, BE and reporting to the NAV-CoE head (Belgium based). The position will play a significant role in shaping current and next generation GSK’s mRNA vaccine platforms to accelerate addressing unmet medical needs, a compelling field having a direct impact into patients and global health. This exciting opportunity allows you to lead key activities, collaborate with top talents in the vaccines industry, and advance your career while ensuring timely project delivery in collaboration with process development colleagues and GMP team. Main core responsibilities Autonomously design, execute, and analyze experiments to develop and optimize RNA downstream processes, ensuring phase-appropriate and scalable processes, as part of the overall platform development strategy. Lead transversally process development activities and/ or any other additional initiatives that may arise. Work within a global downstream team, collaborate transversally with other DS teams, Analytical R&D, GMP teams, etc, in an agile and open way ensuring good communication and alignment. Drive innovative solutions and meet project milestones. Stay up to date on industry trends and emerging technologies in downstream processing, contributing to continuous improvement initiatives. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS or PhD with degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering or a related scientific field 5+ years of industry experience in downstream process development for large biomolecules, preferably mRNA and pDNA, with hands-on experience on a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions. Fluent in English; French is a plus. Experience in overall process development and analytical development activities required for CMC support. Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience with Quality by Design. Experience with DOE studies & high-throughput screen for purification process improvements, and advancements including parameter optimization, scale-up, process window determination and process capability evaluation. Knowledge of the large molecule regulatory environment, particularly FDA/ICH/ISPE guidelines on risk management, technology transfer and process validation Experience and understanding in nucleic acid analytical technologies. If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. 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