We are seeking a GPCR Molecular Pharmacologist to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.

As a member of our Therapeutics Group, you will provide insight and lead GPCR in vitro biology in support of our drug discovery programs, from target assessment through lead optimization. We are a cross-functional group of scientists and drug developers with experience working on all common target classes across therapeutic areas. We are supported by more than 100 software developers and engineers, as well as a large-scale computational infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved Development Candidates, including progression to clinical development and FDA approval. View our entire pipeline of wholly-owned programs and collaborations here.

Who Will Love This Job

A molecular pharmacologist with an in-depth knowledge of GPCR pharmacology A self-starter who has extensive experience with in vitro biology assay development, execution, and troubleshooting A drug discovery scientist who proactively identifies the correlation of heterologous system-based data with those of physiologically relevant cell and in vivo models A team player who enjoys cross-functional collaboration and adapts to changes in program direction, even under tight deadlines A creative, results-oriented, and data-driven scientist interested in multiple disease areas An excellent verbal and written communicator who can convey a compelling message to multiple functions

What You Will Do

Guide in vitro biology strategies for exploratory and early-stage drug discovery efforts Manage experimental design, development, and implementation of cell-based assays for small molecule drug discovery projects Independently train and manage CRO scientists for in vitro biology assay development and compound screening efforts Oversee review, analysis, and interpretation of in vitro data Collaborate with other functional area experts on hit-finding activities in the undrugged target space

What You Should Have

PhD in molecular pharmacology with 1-3  years of experience in pharmaceutical or biotechnology industries; 2-year postdoctoral work focused on GPCRs will be considered In-depth knowledge of the intricacies of multiple signaling pathways, biased signaling, and internalization/recycling of GPCRs Background in in vitro biology assay development and execution as it relates to screening funnels for drug discovery programs Experience in cell-based techniques such as HTRF, NanoBRET, Tag-Lite, and Label-Free technologies (kinetic and endpoint modes) The know-how and perseverance in cracking and interrogating orphan GPCR pharmacology are preferred Experience managing external studies at CROs is preferred   Pay and perks: Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.    Estimated base salary range: $120,000 - $160,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.   Sound exciting? Apply today and join us!   As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.