Institute Associate Scientist III Translational Biology
MD Anderson
MD ANDERSON THERAPEUTICS DISCOVERY DIVISION
Institute Associate Scientist III, Translational Biology
Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics, cellular therapies, and radiopharmaceuticals. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently - all under the same roof.
The Therapeutics Discovery Division is built around multiple platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology), the Neurodegeneration Consortium, and most recently, RADIATE (Radiopharmaceuticals for Advanced Diagnostic Imaging and Therapy).
The RADIATE platform is an industrialized translational research unit that aligns world-class radiopharmaceutical drug discovery and development with highly innovative science and clinical care research. Through an investment in patient-centric research, we have developed the infrastructure, platforms, and capabilities to enable transformative research, partnering with leading clinical research scientists and physicians for which MD Anderson is known. RADIATE's approach combines large scale data science, innovative cancer genetics, disruptive radiopharmaceutical technologies, deep mechanistic biology, disease modeling, and pharmacology to accelerate the translation of novel discoveries.
As part of our mission, RADIATE is focused on partnering with our internal drug discovery engine (IACS, ORBIT, Biologics Development and Cell Therapies, TRACTION) and a growing list of external Partners to discover and develop the next generation of radionuclide theranostics, all driven by the needs we see in our patients.
We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.
SUMMARY
The Institute Associate Scientist III in Translational Biology will be responsible for performing in vitro and in vivo studies to support preclinical development and translational biology of investigational radiopharmaceutical diagnostics and therapy. Activities will include working with project teams through the execution of preclinical cancer models, tracer and therapy adjudication, biological validation, pharamacokinetic, pharmacodynamic and efficacy studies to evaluate exploratory through advanced radiopharmaceutical agents.
KEY FUNCTIONS:
* Under minimal supervision, assists with validating and utilizing novel in vivo xenograft and allograft models.
* Doses animals and analyzes the outcome of pharmacokinetic, pharmacodynamic and efficacy studies.
* Performs survival and non-survival animal surgeries for specimen collection and characterization.
* Utilizes non-invasive imaging.
* Analyzes PET and SPECT data and help with preparation of written and oral reports to project teams.
* Maintains high laboratory standards regarding quality and safety.
* Maintains research records and laboratory notes.
* Other duties as assigned.
CORE COMPETENCIES
Technical/Functional Expertise (Transitional): Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.
Seek experiences and knowledge in technical/functional areas to gain additional expertise. Troubleshoot systems/processes effectively.
Maintain state of the art knowledge in the field. Provide expertise and guidance to others.
Self Motivation (Administrative/Operations Management): Set high standards of performance; pursue goals with energy and persistence; drive for results and achievement in timely manner.
Seek to influence standards with proven business practices. Improve own performance by making specific changes in system or work methods.
Set challenging goals for self and unit. Pursue information to reduce uncertainty for unit.
Self Adaptability (Transitional): Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.
Smoothly handle multiple demands, shifting priorities and rapid change.
Change own immediate behavior or approach to suit the situation. Remain open-minded and adjust approach on basis of new information.
Ability to work well under pressure and drive projects that affect critical timelines.
Team with Others (Transitional): Encourage collaboration and input from all team members; value the contributions of all team members, and those beyond team; balance individual and team goals.
Model team qualities, i.e. respect helpfulness and coping. Support team decisions once they are made and help to implement.
Actively promote a spirit of cooperation and teamwork. Solicit opinions from team members. Coach others in developing teamwork skills.
EDUCATON:
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry, or related field.
EXPERIENCE:
Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.
Preferred: In vivo pharmacology experience including animal handling, dosing, and conducting drug PK/PD and efficacy studies with mice is required; experience with radiation for imaging and/or therapy is preferred.
Experience with in vivo models including subcutaneous and orthotopic xenografts and/or genetically engineered models of cancer. Experience maintaining cell lines in tissue culture, preparing reagents and dosing solutions.
Hands-on experience administering test agents by gavage or intravenous and intraperitoneal injections.
Ability to perform tumor measurements.
Prior experience with minor animal survival and non-survival surgery for specimen collection and characterization.
Experience with in vivo imaging modalities and the evaluation of tissues and biological fluids for molecular and/or biochemical endpoints are desired.
Experience with PET/CT SPECT/CT animal imaging.
The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators, and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information
Requisition ID: 172251 Employment Status: Full-Time Employee Status: Regular Work Week: Days Minimum Salary: US Dollar (USD) 76,650 Midpoint Salary: US Dollar (USD) 95,300 Maximum Salary : US Dollar (USD) 114,975 FLSA: exempt and not eligible for overtime pay Fund Type: Soft Work Location: Onsite Pivotal Position: Yes Referral Bonus Available?: Yes Relocation Assistance Available?: Yes Science Jobs: Yes
#LI-Onsite Apply
Institute Associate Scientist III, Translational Biology
Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics, cellular therapies, and radiopharmaceuticals. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently - all under the same roof.
The Therapeutics Discovery Division is built around multiple platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology), the Neurodegeneration Consortium, and most recently, RADIATE (Radiopharmaceuticals for Advanced Diagnostic Imaging and Therapy).
The RADIATE platform is an industrialized translational research unit that aligns world-class radiopharmaceutical drug discovery and development with highly innovative science and clinical care research. Through an investment in patient-centric research, we have developed the infrastructure, platforms, and capabilities to enable transformative research, partnering with leading clinical research scientists and physicians for which MD Anderson is known. RADIATE's approach combines large scale data science, innovative cancer genetics, disruptive radiopharmaceutical technologies, deep mechanistic biology, disease modeling, and pharmacology to accelerate the translation of novel discoveries.
As part of our mission, RADIATE is focused on partnering with our internal drug discovery engine (IACS, ORBIT, Biologics Development and Cell Therapies, TRACTION) and a growing list of external Partners to discover and develop the next generation of radionuclide theranostics, all driven by the needs we see in our patients.
We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development.
SUMMARY
The Institute Associate Scientist III in Translational Biology will be responsible for performing in vitro and in vivo studies to support preclinical development and translational biology of investigational radiopharmaceutical diagnostics and therapy. Activities will include working with project teams through the execution of preclinical cancer models, tracer and therapy adjudication, biological validation, pharamacokinetic, pharmacodynamic and efficacy studies to evaluate exploratory through advanced radiopharmaceutical agents.
KEY FUNCTIONS:
* Under minimal supervision, assists with validating and utilizing novel in vivo xenograft and allograft models.
* Doses animals and analyzes the outcome of pharmacokinetic, pharmacodynamic and efficacy studies.
* Performs survival and non-survival animal surgeries for specimen collection and characterization.
* Utilizes non-invasive imaging.
* Analyzes PET and SPECT data and help with preparation of written and oral reports to project teams.
* Maintains high laboratory standards regarding quality and safety.
* Maintains research records and laboratory notes.
* Other duties as assigned.
CORE COMPETENCIES
Technical/Functional Expertise (Transitional): Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.
Seek experiences and knowledge in technical/functional areas to gain additional expertise. Troubleshoot systems/processes effectively.
Maintain state of the art knowledge in the field. Provide expertise and guidance to others.
Self Motivation (Administrative/Operations Management): Set high standards of performance; pursue goals with energy and persistence; drive for results and achievement in timely manner.
Seek to influence standards with proven business practices. Improve own performance by making specific changes in system or work methods.
Set challenging goals for self and unit. Pursue information to reduce uncertainty for unit.
Self Adaptability (Transitional): Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.
Smoothly handle multiple demands, shifting priorities and rapid change.
Change own immediate behavior or approach to suit the situation. Remain open-minded and adjust approach on basis of new information.
Ability to work well under pressure and drive projects that affect critical timelines.
Team with Others (Transitional): Encourage collaboration and input from all team members; value the contributions of all team members, and those beyond team; balance individual and team goals.
Model team qualities, i.e. respect helpfulness and coping. Support team decisions once they are made and help to implement.
Actively promote a spirit of cooperation and teamwork. Solicit opinions from team members. Coach others in developing teamwork skills.
EDUCATON:
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry, or related field.
EXPERIENCE:
Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.
Preferred: In vivo pharmacology experience including animal handling, dosing, and conducting drug PK/PD and efficacy studies with mice is required; experience with radiation for imaging and/or therapy is preferred.
Experience with in vivo models including subcutaneous and orthotopic xenografts and/or genetically engineered models of cancer. Experience maintaining cell lines in tissue culture, preparing reagents and dosing solutions.
Hands-on experience administering test agents by gavage or intravenous and intraperitoneal injections.
Ability to perform tumor measurements.
Prior experience with minor animal survival and non-survival surgery for specimen collection and characterization.
Experience with in vivo imaging modalities and the evaluation of tissues and biological fluids for molecular and/or biochemical endpoints are desired.
Experience with PET/CT SPECT/CT animal imaging.
The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators, and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information
Requisition ID: 172251 Employment Status: Full-Time Employee Status: Regular Work Week: Days Minimum Salary: US Dollar (USD) 76,650 Midpoint Salary: US Dollar (USD) 95,300 Maximum Salary : US Dollar (USD) 114,975 FLSA: exempt and not eligible for overtime pay Fund Type: Soft Work Location: Onsite Pivotal Position: Yes Referral Bonus Available?: Yes Relocation Assistance Available?: Yes Science Jobs: Yes
#LI-Onsite Apply
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