The Mouse Immunotherapy Research Technician will participate in research studying the beneficial and harmful effects of T cells in the context of bone marrow transplantation and adoptive T cell immunotherapy of cancer. T cells from the bone marrow transplant donor can attack leukemia cells, but they also can damage normal tissues causing graft-vs-host disease. Understanding the biology of these processes is key for improving outcomes in the clinic. Similarly, T cells can recognize mutant proteins in cancer cells, but this process is not naturally strong enough to prevent cancer. The lab studies the nature of T cells that infiltrate tumors and the creation of T cell products that target these mutant proteins. The new hire will work with novel gene modified mice (including those made by the PI), CRISPR-editing of mouse leukemias, adoptive T cell immunotherapy, high-throughput genomic techniques and state of the art mouse model systems. The candidate will be trained in some or all of the following areas: molecular and cell biology techniques, the handling of mice and the principles of cellular and molecular immunology as they relate to blood and marrow transplantation and cancer immunology.

Performs a variety of laboratory experiments and procedures. Prepares specimens. Oversees supply management. Operates and properly maintains equipment.

Performs a variety of laboratory experiments and procedures. Prepares specimens. Oversees supply management. Operates and properly maintains equipment.

The candidate must be capable with training to perform the techniques and work described above, without accommodation.