Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.
The PositionRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.
Postdoctoral researcher in computational oncology: integrative analysis of multimodal data in triple negative breast cancer
Who we are: Institut Roche is a non-commercial affiliate of Roche located in Boulogne, near Paris, France, dedicated to the development and management of pre-clinical and translational collaborative projects between Roche and the academic ecosystem. Institut Roche’s team includes almost exclusively PhDs with expertise ranging from immunology to neuroscience and oncology, and several data and analytics experts. Institut Roche boasts strong connections to the wide Roche ecosystem, in particular the research centers in Basel (pRED) and South San Francisco (Genentech). Roche is a global leader in pharmaceutical research, pioneer in the field of immuno-oncology and second top pharma R&D investor worldwide.
The position: The postdoctoral researcher will be in charge of integrative analysis for the Cassiopeia project, a collaborative project taking place at Institut Curie in Paris, France. The goal of Cassiopeia project is to create a significant paradigm shift in the clinical care of patients with Triple-Negative Breast Cancer (TNBC). TNBC is frequently diagnosed in young women, with an incidence of 9,000 to 15,000 new cases annually, and is associated with a poor prognosis—a survival rate of 60%. These patients face a higher risk of early metastatic recurrence and have a shorter overall survival compared to other breast cancer subtypes. Over the last decade, chemotherapy has been the sole systemic therapeutic option, offering limited efficacy. There remains a critical need for the identification of biomarkers to pinpoint patients at high risk of relapse and those who are resistant to treatment.
The postdoctoral researcher will be leading the integrative analysis of multimodal data generated in Cassiopeia, including scRNA-seq, spatial transcriptomics, clinical data, multiplex IHC, radiomic, TCR-seq and ctDNA. The position will require building a clinically relevant strategy for multimodal feature selection, integration and response association/prediction. The postdoctoral researcher will be tasked with maintaining and strengthening collaboration with internal teams in Basel and South San Francisco on the Cassiopeia project, and leveraging computational skills across the entire organization. The overarching goal of the project is to better understand and overcome resistance to therapy in triple negative breast cancer.
Who you are:
You have a PhD in computational biology, bioinformatics, biophysics or equivalent quantitative fieldYou have experience analyzing various biological datasets, including NGS such as single cell RNA-seq or spatial transcriptomicsYou have experience integrating different data modalities in biology for the purpose of insights generation, patient stratification and outcome predictionYou have experience in machine learningYou can code efficiently in R/PythonYou have experience in project managementYou are agile, creative and solution orientedYou are skilled at communicating your research to stakeholders with various backgroundsYou are fluent in EnglishExperience in image analysis preferredExperience in Deep learning preferredExperience in oncology and immunology preferredExperience in multimodal analysis is a plus
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Roche is an Equal Opportunity Employer.
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Roche is an Equal Opportunity Employer.