Vacancy ID: PDS004087 Position Summary/Description: One postdoctoral associate position is available in a cancer research lab located within the University of North Carolina at Chapel Hill Lineberger Cancer Center. The lab currently studies the hypoxia signaling, prolyl hydroxylases, and cancer, specifically breast and renal cell carcinoma. One project focuses on using novel proteomic and genomic approaches to screen for novel prolyl hydroxylase substrates that play important roles in various of cancer. The other project involves integrating ChIP-seq strategy with gene expression profiling to identify EglN2 prolyl hydroxylase and Hypoxia-inducible factor 1 (HIF1) targets in the malignant diseases. The ultimate goal is to understand mechanistically how oxygen-sensing pathways contribute to cancer progression, which will facilitate our design of an effective treatment strategy to target cancer specifically. Besides these major research directions, we are also interested in studying the mechanism of chromosomal instability in cancer, specifically related to FBW7 tumor suppressor pathways. Education and Experience: Strong background in molecular/cell biology, biochemistry, and cancer biology.