Postdoctoral Research Fellow - Gastroenterology Research Center **Location:** Texas Medical Center-Houston, Texas **Category:** Post Doctoral Research Fellow McGovern Medical School at UTHealth Houston Requisition #: 250000C9 **What we do here changes the world.** UTHealth Houston is Texas’ resource for healthcare education, innovation, scientific discovery, and excellence in patient care. That’s where you come in. **Once you join us you won't want to leave.** It’s because we reward our team for the excellent service they provide. Our total rewards package includes the benefits you’d expect from a top healthcare organization (benefits, insurance, etc.), plus: + 100% paid medical premiums for our full-time employees + Generous time off (holidays, preventative leave day, both vacation and sick time – all of which equates to around 37-38 days per year) + The longer you stay, the more vacation you’ll accrue! + Longevity Pay (Monthly payments after two years of service) + Build your future with our awesome retirement/pension plan! **We take care of our employees!** As a world-renowned institution, our employees’ wellbeing is important to us. We offer work/life services such as... + Free financial and legal counseling + Free mental health counseling services + Gym membership discounts and access to wellness programs + Other employee discounts including entertainment, car rentals, cell phones, etc. + Resources for child and elder care + Plus many more! **Position Summary:** A postdoc position provides an opportunity for early-career researchers to gain valuable experience, develop independent research skills, and contribute to the advancement of scientific knowledge in their field of expertise. The post-doctoral fellow will work independently in a multidisciplinary supervised environment on murine and patient derived samples to study pathogenesis of GI diseases including aging pathways and cancer. The selected candidate has experience working with cell culture and cell treatments as well as with lab-based assays including protein and RNA based techniques. The post doc is expected to be able to draft results of the studies being generated on circadian and microbiota experiments. **Position Key Accountabilities:** 1. Interpret and prepare results on omics data (circadian and microbiome related). 2. Develop and maintain organoids from human and mice samples. 3. Develop and maintain immune cells (i.e., macrophages, myofibroblasts, T cells). 4. Conduct in vitro growth of organoids, and immune cells, and perform and optimize co-culture experiments in transwell. 5. Perform DNA extraction, gene expression (qPCR) and protein measurements (western blot, ELISA, and immunofluoresence). 6. Perform co-culture and optimize drug testing on cells and organoids 7. Be familiar with high throughput knock in and knock out cell-based screening. 8. Be familiar with liver image monitoring based on luciferase and fluorescence signals. 9. Work closely with bioinformatics platforms and scientists to generate outputs from circadian and microbiota data. 10. Analyze data and generate figures using scientific computer software (SPSS, R, Prism) and share data with the group for feedback as well as troubleshooting 11. Performs other duties as assigned. **Minimum Education:** Doctoral/Terminal Degree Knowledge: Molecular biology, in vitro and in vivo experience Analytical, interpersonal ability to identify needs for projects and ordering appropriate equipment and necessary supplies to conduct studies Abilities:Proficiency with Microsoft Office, scientific computer software (R, Prism) and basic imaging modalities (Adobe Photoshop, imageJ); Knowledge of handling database **Physical Requirements:** Exerts up to 20 pounds of force occasionally and/or up to 10 pounds frequently and/or a negligible amount constantly to move objects. **Security Sensitive:** This job class may contain positions that are security sensitive and thereby subject to the provisions of Texas Education Code § 51.215 **Residency Requirement:** Employees must permanently reside and work in the State of Texas. If you are looking for a great healthcare career in Houston, visithttp://go.uth.edu/careers! **University of Texas Health Science Center at Houston (UTHealth)** Established in 1972 by The University of Texas System Board of Regents, The University of Texas Health Science Center at Houston (UTHealth) is Houston’s Health University and Texas’ resource for health care education, innovation, scientific discovery and excellence in patient care. The most comprehensive academic health center in the UT System and the U.S. Gulf Coast region, UTHealth Houston is home to schools of biomedical informatics, biomedical sciences, dentistry, nursing and public health and the John P. and Kathrine G. McGovern Medical School. UTHealth Houston includes The University of Texas Harris County Psychiatric Center, as well as the growing clinical practices UT Physicians, UT Dentists and UT Health Services. The university’s primary teaching hospitals are Memorial Hermann-Texas Medical Center, Children’s Memorial Hermann Hospital and Harris Health Lyndon B. Johnson Hospital. **UTHealth Benefits** UTHealth Houston offers a comprehensive and competitive benefits package. For more information on our benefits programs please refer to the UTHealth Houston Office of Benefits Website. https://www.uth.edu/benefits/ **Equal Employment Opportunity Statement** UTHealth Houston is committed to providing equal opportunity in all employment-related activities without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status or any other basis prohibited by law or university policy. Reasonable accommodation, based on disability or religious observances, will be considered in accordance with applicable law and UTHealth Houston policy. The University maintains affirmative action programs with respect to women, minorities, individuals with disabilities, and eligible veterans in accordance with applicable law. UTHealthHoustonhas adopted a policy consistent with CMS regulations to protect our patients and university community from exposure to COVID-19. This policy affects all employees, residents, fellows, students, contractors, new hires, visiting scholars program participants, adjunct faculty, and volunteers who work, train, or collaborate at the John S. Dunn Behavioral Science Center. In addition, all UTHealthHouston​​​​​​​employees who are assigned to work at a location that is subject to the affiliated partner’s hospital, clinical offices, or agency are required to abide by UTHealth’sHoustonrules and regulations, as well as the affiliate’s rules and regulations, including COVID-19 vaccination and safety requirements. Work location is based on the needs of the department and may be adjusted.