Institute of Molecule Medicine - Proteolysis targeted cancer drug discovery

Postdoctoral Research Fellow Position in Cancer Drug Discovery

A postdoctoral position is available to discover novel protein-based therapeutics for cancer treatment in the laboratory, Center for Translational Cancer Research, Brown Foundation Institute of Molecular Medicine. The laboratory is focused on understanding the function and mechanism of LGR4/5/6 (leucine-rich repeat-containing, G protein-coupled receptor 4, 5, and 6) in Wnt signaling and targeting the three receptors for cancer treatment. LGR4/5/6 are abundantly expressed in gastrointestinal cancer with LGR5 being a marker of cancer stem cells/tumor-initiating cells. Our lab is using multiple approaches that target LGR4/5/6 for the treatment of gastrointestinal cancer, including drug conjugates of modified ligands and proteolysis targeting of oncogenes. The postdoctoral position will focus on the creation and characterization of bi-specific molecules that target oncogenic driver genes and immune modulators for degradation using cutting edge technology of drug discovery.

Minimum Requirements:

A Ph.D. in the field of biochemistry, cell biology, cancer biology, pharmacology, or therapeutics.

Description of Qualified Candidates:

Experience with molecular cloning, protein purification, cancer cell line culturing, and xenograft cancer models are highly desirable but not required.

 

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Position Summary:

A postdoc position provides an opportunity for early-career researchers to gain valuable experience, develop independent research skills, and contribute to the advancement of scientific knowledge in their field of expertise.

Minimum Education:

Doctoral/Terminal Degree

Prefer a Ph.D. in the field of biochemistry, cell biology, cancer biology, pharmacology, or therapeutics. Experience with molecular cloning, protein purification, cancer cell line culturing, and xenograft cancer models are highly desirable but not required.

Physical Requirements:

Exerts up to 20 pounds of force occasionally and/or up to 10 pounds frequently and/or a negligible amount constantly to move objects.

Security Sensitive:

This job class may contain positions that are security sensitive and thereby subject to the provisions of Texas Education Code § 51.215

Residency Requirement:

Employees must permanently reside and work in the State of Texas.