Site Name: UK - Cambridgeshire - Addenbrookes Posted Date: Nov 5 2024 We are looking for a talented Principal Scientist with expertise in spatial and single cell (SC) technologies to join the Biomarker and Bioanalytical Platform (BBP) department in Precision Medicine (PMed) based at Clinical Unit Cambridge (CUC) in Cambridge, UK. This GCP laboratory-based position will work on clinical translational projects across GSK’s respiratory, immunology, and emerging specialties portfolio to generate data sets to increase the understanding of disease heterogeneity, drug’s mechanism of action, and patient responses to treatment at the molecular level. The person will perform routine histological and cutting-edge spatial-omic and single cell experiments on clinical trial patient biopsies to generate quantitative analytical data. This role will provide you with the opportunity to lead key translational projects and closely collaborate and support research teams, GSK matrix partners, and external academic institutes. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK Key Responsibilities: Histotechnology: Perform routine histotechnology including biopsy processing, microtomy, histochemical staining and slide scanning to QC and prepare samples for downstream spatial or SC analysis. Single-cell processing: Process various matrices for single-cell/nuclei analysis, using the Chromium X and Next Generation Sequencing. Spatial-omics: Use spatial-omic platforms, including Xenium and Visium. Perform spatial data analysis using off-the-shelf analysis workflows. Lab Compliance: Compile QC reports and write standard operating procedures, analytical methods, and protocols and record data in-line with GCP lab standards. Cross-functional Collaboration: Work closely with multidisciplinary teams including Translational Research, Translational Sciences, Precision Medicine, HBSM, and Pathology. Provide guidance on assay platforms and capabilities. Adjust priorities as needed to meet required deadlines. Professional Development: Provide necessary training and help troubleshoot issues within the team. Develop trusted connections in the scientific community (internally and externally to GSK) through meetings, publications and presentations at conferences hosted by professional societies. Why you? Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: Master’s degree in biological sciences or a relevant scientific field (e.g., immunology, molecular biology, cancer biology, neurobiology, genomics). Possess a broad knowledge of histotechnology and spatial-omics to help guide teams towards the best-suited platforms and high-plex assays for their needs. Skilled in routine histology (biopsy processing, microtomy, histochemical staining and slide scanning). Experienced in processing various tissues for single-cell/nuclei analysis, and familiar with using the Chromium X. Experienced in working with spatial-omic platforms Visium and Xenium, including the design, implementation and troubleshooting of spatial-omics experiments. Team player familiar with working in a matrixed environment, on multiple projects, and be able to and meet strict deadlines. Strong attention to detail, experimental execution and record keeping. Willingness to develop and train others as required. Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: PhD in biological science or a relevant scientific field (e.g., immunology, molecular biology, cancer biology, neurobiology, genomics). Experience working in a GCP setting. A good understanding of the drug development process from previous experience working in a biopharmaceutical environment. Experienced in workflows to analyze high-plex biological data sets. Experience generating high quality data to support clinical studies by various spatial and single cell platforms. Closing Date for Applications – 19 Nov 2024 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together. Find out more: Our approach to R&D. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. 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