Description

Job Title:

Principal Scientist, Neurobiology

Location:

San Diego, CA

Position type:

FLSA:

Full time

Exempt

Department:

Finance ID:

Biology

7300-2023-1-P

Strive to Bring a Profound Difference to our Patients

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and Twitter.

The Opportunity

Avidity Biosciences is seeking an experienced and motivated Principal Scientist to drive the development of innovative therapeutic drugs for neurological diseases. The successful candidate will play a pivotal role in driving our siRNA therapeutic projects from discovery through preclinical development, working collaboratively with cross-functional teams to advance our mission of developing groundbreaking RNA-based treatments. The individual should have a proven track record in neurobiology and experience developing therapeutics for neuromuscular diseases.

What You Will Contribute

Leadership & Strategy:Provide scientific leadership in the area of neurobiology and function in the planning and execution of siRNA-based therapy projects targeting neurological diseases.Provide scientific and technical leadership to a team of researchers, fostering a collaborative and innovative environment.Develop and implement project plans, timelines, and budgets to ensure successful project delivery.Research & Development:Responsible for developing and implementing in vitro and in vivo assays and models to evaluate various agents for delivering RNAs across the blood-brain barrier and to peripheral and central neuronal cellsOversee the design, development, and optimization of siRNA molecules for targeted gene silencing in animal models.Ensure the robustness and reproducibility of early discovery studies, including in vitro and in vivo experiments.Stay abreast of the latest advancements in siRNA technology, genetic neuromuscular diseases, and related therapeutic areas to inform and guide research efforts.Collaboration & Communication:Collaborate with internal and external stakeholders, including academic partners, CROs, and regulatory agencies, to drive project success.Present research findings and project updates to senior management, scientific advisory boards, and external partners.Contribute to preparing scientific publications, patents, and regulatory submissions.Team Development:Mentor and develop team members, fostering their professional growth and technical expertise.Promote a culture of excellence, inclusivity, and continuous learning within the team.

What We Seek

PhD in neurobiology with a focus on cellular biology and neuromuscular diseasesA minimum of 10+ years of relevant working experience, preferably in the biopharmaceutical industry, with a strong track record in developing therapeutics.In-depth knowledge of neurobiology and in vitro and in vivo modelsProven experience in leading and managing research teams and projects.Demonstrated ability to work collaboratively in a fast-paced, multidisciplinary environment.Excellent project management skills with the ability to prioritize tasks and manage multiple projects simultaneously.Demonstrated excellent communication (oral and written), teamwork, organizational, interpersonal, and problem-solving skills.A strong understanding of siRNA delivery technologies is preferred.Ability to travel as needed for work-related meetings and conferences. What We Will Provide to You:The base salary range for this role is $166,250 - $183,750. The final compensation will be commensurate with factors such as relevant experience, skill set, internal equity, and market factors.Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, RSUs, and a 401(k) with an employer match. In addition, the comprehensive wellness program includes medical, dental, vision, and LTD coverage and four weeks of time off.A commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

Avidity Biosciences

10578 Science Center Dr. Suite 125

San Diego, CA

92121

O: 858-401-7900

F: 858-401-7901

 

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