**Job Description** Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. We deliver robust scientific data and interpretation that drives the development and commercialization of breakthrough therapeutics. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology, we collaborate to discover the next medical breakthrough. The Analytical Research and Development, Cell Based Sciences Department in West Point, PA is seeking a Principal Scientist with technical expertise in developing large molecule potency assays. In this role, an individual will work closely with the group Director to define technical and scientific strategies and lead a team of scientists in solving complex analytical problems to facilitate the development of vaccines. The ideal candidate will be an expert in developing mechanism-of-action reflective potency assays for the development of multi-valent recombinant vaccine products. We are looking for a collaborator with strong leadership skills and ability and passion for mentoring and working with others in a laboratory setting. This position will involve leading laboratory development to drive understanding of vaccine development, partnering across functions and divisions to strategically apply that understanding to deliver the best analytical science in the process and product will be key to success. The successful candidate is expected to provide scientific leadership, expertise, and creativity to solve complex project problems across the large molecule portfolio. Applicants must have effective organizational and multi-tasking skills, have demonstrated excellent scientific leadership, and have superior written and oral communications skills. The candidate will be expected to effectively communicate with stakeholders in partner organizations and to management and governance teams. Experience leading small groups of technical personnel, leading projects, and defining group or departmental strategy will aid in distinguishing candidates. An established reputation for scientific excellence supported by publications and external presentations is expected. **Primary Responsibilities:** + Lead, supervise, and mentor a team of scientists developing analytical methods and defining the potency strategy for our large molecule portfolio. + Provide analytical leadership not only on vaccine development pipeline projects, but also innovative technology teams shaping analytical methods and tools of the future. ​ + Representing the group on product development teams, Work and collaborate effectively in a multidisciplinary team environment and provide technical input to enable team decisions. + Lead in authoring and reviewing scientific documents including development reports, analytical method protocols, qualification protocols, and electronic notebooks. + Work and collaborate effectively in a multidisciplinary team environment and provide technical input to enable team decisions. + Be a leader within the external scientific community in professional organizations, conferences, and publica­tions as well as analytical technology and regulatory sciences related focus groups and consortia. **Education Requirements:** + Ph.D. in analytical chemistry, molecular biology, cell biology, virology, or related field with a minimum of **8** years of relevant experience in Biopharmaceutical Industry; + OR M.S. with a minimum of **10** years of relevant experience in Biopharmaceutical Industry; + OR Bachelor’s with a minimum of **14** years of relevant experience in Biopharmaceutical Industry. **Required Skills and Experience:** + In-depth knowledge and understanding of immunoassay development including antigen and antibody selection, antibody matched pair screening and optimization, binding kinetics, and multiplexing. + Expertise in cell biology and immunology, with application to solve complex scientific challenges related to designing and developing GxP potency assays to support a variety of vaccine modalities. + Demonstrated ability to lead complex experimental design and detailed data analysis concepts related to analytical method development. + Deep working knowledge of regulatory guidance and quality standards, with experience authoring and reviewing regulatory submissions and responses (biologics license application submission) and interacting with Health Authorities. + Ability to excel in a team-based environment, partnering and influencing in a professional and positive manner. + External scientific engagement demonstrated through publications, regulatory guidance documents, industry white paper contributions, presentations at scientific meetings, and/or membership on (or leading) cross-company working groups or consortia. + Excellent verbal and written communications skills. Please note that this lab-based role is not eligible for our hybrid work model, but we are committed to promoting work-life balance and offer other flexible arrangements where feasible. \#AR&D Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld) Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld) **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process. We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088\_EEOC\_KnowYourRights\_10\_20.pdf) EEOC GINA Supplement​ Pay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp\_%20English\_formattedESQA508c.pdf) We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/) **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** **VISA Sponsorship:** **Travel Requirements:** **Flexible Work Arrangements:** Not Applicable **Shift:** **Valid Driving License:** **Hazardous Material(s):** **Job Posting End Date:** 03/20/2025 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R336102