**Principal Scientist** Laboratory Santa Clara County , CA, US Pay Rate Low: 160000 | Pay Rate High: 172000 + Added - 07/02/2025 Apply for Job _Our client, a leading biopharmaceutical company focused on developing innovative therapies, is looking for a Principal Scientist to join their team in Santa Clara County, California!_ **Location:** Santa Clara County, CA **Salary:** $160k- $172k/ annually, with a 12% bonus potential and full benefits **Job type:** Direct hire **Job Description:** The Principal Scientist will lead the IHC team and report to the Director of IHC and oversee histopathology work and mentoring junior staff. This role focuses on IHC, immunofluorescence, ISH, and microscopy, with an emphasis on oncology and tumor/immune cell targets. The position involves assay development, tissue processing, and antibody validation, while coordinating research efforts and presenting data internally and externally. **Responsibilities:** + Lead histopathology activities including tissue collection, IHC, ISH, and staining + Develop and validate IHC assays (manual and automated) + Mentor junior team members and collaborate with stakeholders + Present data on research projects to internal teams and external collaborators + Support oncology research and contribute to biomarker strategies using advanced technologies + Manage research projects in a fast-paced environment **Requirements:** + PhD (or Bachelor’s/Master’s with 10+ years of experience) in life sciences or related field + Extensive experience in histology, IHC, ISH, and microscopy (including chromogenic and fluorescent staining) + Strong expertise in antibody discovery, digital pathology, and image analysis + Proven ability to lead projects and present data to both technical and non-technical audiences + Experience working with CROs and service providers + Experience in companion diagnostics (CDx) and tissue culture \#LIDNP \#INDBH We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.