**Join Amgen’s Mission of Serving Patients** At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Principal Scientist Medicinal Chemistry** **What you will do** Let’s do this. Let’s change the world. In this vital role the Principal Scientist role will be part of an innovative Medicinal Chemistry group, with primary responsibilities being the design of novel compounds for potential clinical development, while also serving as a Project Team Representative. This Principal Scientist role will typically manage a large external synthetic chemistry team and work together with a diverse cross-functional team of research scientists to help determine team direction and advance programs in Amgen’s small molecule portfolio. Additional responsibilities include but are not limited to regularly communicate progress and strategy in various forums. This role can be in the department of Medicinal Chemistry at our Research and Development facility in Thousand Oaks CA (ATO). This role also has the option to be remote, with occasional travel to ATO required. **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The professional we seek has these qualifications: **Basic Qualifications:** Doctorate degree and 2 years of scientific experience Or Master’s degree and 5 years of scientific experience Or Bachelor’s degree and 7 years of scientific experience **Preferred Qualifications:** + Doctorate degree in chemistry specializing in organic chemistry and 7+ years of experience in synthetic organic and medicinal chemistry + Experience leading medicinal chemistry teams and delivering candidates for clinical development + Extensive track record of consistent and successful drug discovery accomplishments (e.g. patent inventor-ship, conference presentations, and peer-reviewed publications) + Deep understanding of drug discovery and relevant drug discovery disciplines (e.g. chemistry, biology, safety, PKDM, etc.) + Expert in modern medicinal and synthetic chemistry approaches + Excellent collaboration and communication skills (both written and oral) **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models, including remote and hybrid work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. **Application deadline** Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.