Job requirements
This position is intended for collaborative research working on X chromosome dosage compensation mechanisms in mouse and humans and the role of X-linked gene expression in the placenta. The Plath lab uses cutting-edge stem cell biology, mouse models, gene regulation, imaging, and omics techniques to study these questions.

The preferred qualifications for this position are as follows:

Ph.D. in Gene Regulation, Biochemistry, Cell Biology, Developmental Biology, Stem Cell Biology, or a related field. At least 3 years of postdoctoral experience with a strong publication and collaborative record. Expertise in X-chromosome dosage compensation. Proficiency in molecular biology techniques, including RNA-seq, ATAC-seq, CRISPR-Cas9 genome editing, and advanced imaging. Experience in bioinformatics and analyzing single cell and bulk genomics dat. Strong organizational, problem-solving, and communication skills. Demonstrated ability to lead independent projects and work collaboratively within a team.

Job duties and responsibilities

Design and conduct experiments to dissect molecular mechanisms underlying gene expression dosage compensation on the X chromosomes in placental mammals and apply genetic approaches to test functional relationships. Lead and execute projects focused on the understanding the role of X-linked genes expression in the placenta, at the feto-maternal interphase. Use state-of-the-art omics including genomics, metabolomics, proteomics and imaging techniques to characterize cell populations and lineage specification and their X-linked gene expression in vivo and in vitro. Utilize mouse models and human tissues in addressing questions of interest. Perform the analyses and interpretation of resulting genomics data. Develop and optimize protocols for the analysis of the mouse placenta by single cell and single nucleus genomics approaches. Collaborate with other lab members and external collaborators to integrate multi-disciplinary approaches into the studies of X-chromosome dosage compensation. Mentor junior scientists, postdocs, and students in experimental design, data analysis, and scientific writing. Contribute to the preparation of research manuscripts for publication, grant proposals, and progress reports and gather pilot data for grant proposals. Responsible for the maintenance of lab instruments and training new users in their operation. Help with safety protocols. Seek funds to establish own independence.