Job Description

The world's most revolutionary biopharma companies are partnering with Agilent Technologies to advance the next frontier of medicine. Agilent continues to invest in the capacity and expansion of its Colorado operations. Join our team of professionals dedicated to the development and commercialization of nucleic acid therapeutics for life-changing, life-saving medicines.

Position Responsibilities:

Understands product requirements by studying and implementing oligonucleotide project objectives and targets related to engineering and chemical requirements.

Assists project development by developing synthetic routes, methods, and techniques in preparing, separating, purifying, analyzing, quantifying and resolving oligonucleotide process components and objectives.

Maintains process compliance integrity by adhering to standard operating procedures (SOP's) and current good manufacturing practices (cGMP) as appropriate.

Documents analyses by completing experiment notebooks and records; implementing process chemistry applications and analyzing results of new oligonucleotide synthesis and purification methods and processes.

Sets-up and operates laboratory equipment by following operating instructions; troubleshooting instrumentation and method issues. Applies laboratory experience in chemistry and separations to issues of process optimization, scale-up and laboratory process transfer to mid and kilo scale GMP manufacturing.

Executes Design of Experiments (DOE) and Proven Acceptable Range (PAR) experiments to support design space understanding and process validation as they relate to oligonucleotide synthesis, process chromatography, and other purification and isolation techniques.

Assists with the preparation of milligram to gram quantities of active pharmaceutical ingredient (API) to support early-stage (Pre-clinical) development and toxicology studies.

Helps with the preparation of process descriptions and the writing of technical reports to support internal technology transfer into manufacturing and support in preparation of client CMC submissions.

Improves job knowledge by understanding emerging trends in oligonucleotide analytical methods and synthesis development; reviewing professional and technical publications; establishing personal networks and benchmarking state-of-the-art practices.

Qualifications

Bachelor’s or Master’s Degree in chemistry, chemical engineering, science or equivalent or a combination of education and or experience

1+ years relevant experience working in a pharmaceutical environment preferred

Previous knowledge of oligonucleotide synthesis, purification, ultrafiltration, conjugation, and lyophilization is a plus

Detail-oriented and can perform technical duties following standard operating procedures and general laboratory safety rules.

Ability to work both independently and in a team setting on a variety of projects and use individual discretion to meet required project objectives and deadlines

Excellent math, documentation, communication and operational troubleshooting skills

Requires general proficiency with tools, systems and procedures to accomplish job

#LI-DT1

The US pay range for this full-time position is $74,560.00 - $116,500.00/yr, plus eligibility for bonus, stock and benefits. Our pay ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum new hire pay for the position across the relevant US locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, a recruiter can share more about the specific pay range for a preferred location. Additional details are available at:  https://careers.agilent.com/locations/americas/united-states/

Additional Details

This job has a full time weekly schedule. Applications for this job will be accepted until at least November 12, 2024 or until the job is no longer posted.

The full-time equivalent pay range for this position is $74,560.00 - $116,500.00/yr plus eligibility for bonus, stock and benefits. Our pay ranges are determined by role, level, and location. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, a recruiter can share more about the specific pay range for a preferred location. Pay and benefit information by country are available at: https://careers.agilent.com/locations

Agilent Technologies, Inc. is an Equal Employment Opportunity and Affirmative Action employer. We value diversity at all levels. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to sex, pregnancy, race, religion or religious creed, color, gender, gender identity, gender expression, national origin, ancestry, physical or mental disability, medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military or veteran status, protected veteran status, or any other basis protected by federal, state, local law, ordinance, or regulation and will not be discriminated against on these bases. Agilent Technologies, Inc., is committed to diversity in the workplace and strives to support candidates with disabilities. If you have a disability and need assistance with any part of the application or interview process or have questions about workplace accessibility, please email job_posting@agilent.com or contact +1-262-754-5030. For more information about equal employment opportunity protections, please visit www.agilent.com/en/accessibility.

Travel Required: No

Shift: Day

Duration: No End Date

Job Function: R&D