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In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
This position is anchored into the Nucleic Acid-based Medicines (NABM). The position holder will be member of the Viral Technology group.
The Viral Technology group areas of focus encompass rAAV manufacturing, AAV vector & capsid engineering, and plasmid engineering, with the final goal to improve the therapeutic potential of AAV-based gene therapies.

Role Mission
We are offering an outstanding opportunity for a Research associate to work within a multidisciplinary team dedicated to engineering and producing new rAAV to supply internal research groups and overall improve rAAV product quality. You will participate in, but not be limited to, molecular cloning and research grade plasmids production to support research grade rAAV vectors production.

Your Impact

Execute plasmid preparation following manual Midi, Maxi, Gig prep processes

Perform plasmid characterization through either automated platform or manual protocol

Perform molecular cloning and AAV vector cloning

Assist in the development and optimization of high throughput plasmid production

Maintain raw material supplies and reagents for plasmid preparation

Assist and implement workflow for end to end DNA to rAAV supply

Participate in laboratory management: lab organization, ordering, equipment, maintenance and qualification, etc…

Thoroughly document performed experiments in our electronic laboratory documentation system and present findings in internal as well as external meetings and events.

Your Profile

You are an enthusiastic scientist with a background in biotechnology, biology,
bioengineering, biochemistry or a relevant life science field. You bring interest and hands-on experience in plasmid, molecular cloning strategies, purification & characterization, AAV proteins design, shRNA via AAV, mi-RNA/AAV, NGS library preparation for AAV variant screening.

You thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development. You have a keen interest in continuously building a personal network. You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner. You have a sense for ensuring that everyone has the required information at all times. You have strong oral and written communication skills and are proficient in working with cross-functional and multidisciplinary teams.

We look forward to receiving your application!

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

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Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

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