Job Description

The world's most revolutionary biopharma companies are partnering with Agilent Technologies to advance the next frontier of medicine. Agilent continues to invest in the capacity and expansion of its Colorado operations. Join our team of professionals dedicated to the development and commercialization of nucleic acid therapeutics for life-changing, life-saving medicines.

Position Responsibilities:

Understands product requirements by studying and implementing oligonucleotide project objectives and targets related to engineering and chemical requirements.

Leads project development by developing synthetic routes, methods, and techniques in preparing, separating, purifying, analyzing, quantifying and resolving oligonucleotide process components and objectives.

Leads the preparation of milligram to gram quantities of active pharmaceutical ingredient (API) to support early-stage (Pre-clinical) development and toxicology studies.

Independently sets-up and operates unit operation experiments, troubleshooting and solving instrumentation, methods, and process issues. Applies laboratory experience in chemistry and separations to issues of process optimization, scale-up and laboratory process transfer to mid and kilo scale GMP manufacturing.

Independently executes Design of Experiments (DOE) and Proven Acceptable Range (PAR) experiments to support design space understanding and process validation as they relate to oligonucleotide synthesis, chromatography, and other purification and isolation techniques.

Implements process chemistry applications and analyzing results of new oligonucleotide synthesis and purification methods and processes.

Documents results and analyses by completing experiment notebooks and records. Prepares process descriptions, presentations, and writes technical reports to support internal technology transfer into manufacturing and client communications.

Maintains process compliance integrity by adhering to standard operating procedures (SOP's) and current good manufacturing practices (cGMP) as appropriate.

Understands oligonucleotide chemistry and analytical methods and follows the development of oligonucleotide technologies from professional and technical news and publications.

Qualifications

Bachelor’s or Master’s Degree in chemistry, chemical engineering, or related life sciences field

4+ years of experience working with oligonucleotides

Previous knowledge and experience of oligonucleotide process development and analysis is helpful

Detail-oriented and can perform technical duties under minimal supervision

Ability to work both independently and in a team setting on a variety of projects and use individual discretion to meet required project objectives and deadlines

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Additional Details

This job has a full time weekly schedule. Applications for this job will be accepted until at least November 13, 2024 or until the job is no longer posted.

The full-time equivalent pay range for this position is $79,200.00 - $123,750.00/yr plus eligibility for bonus, stock and benefits. Our pay ranges are determined by role, level, and location. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, a recruiter can share more about the specific pay range for a preferred location. Pay and benefit information by country are available at: https://careers.agilent.com/locations

Agilent Technologies, Inc. is an Equal Employment Opportunity and Affirmative Action employer. We value diversity at all levels. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to sex, pregnancy, race, religion or religious creed, color, gender, gender identity, gender expression, national origin, ancestry, physical or mental disability, medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military or veteran status, protected veteran status, or any other basis protected by federal, state, local law, ordinance, or regulation and will not be discriminated against on these bases. Agilent Technologies, Inc., is committed to diversity in the workplace and strives to support candidates with disabilities. If you have a disability and need assistance with any part of the application or interview process or have questions about workplace accessibility, please email job_posting@agilent.com or contact +1-262-754-5030. For more information about equal employment opportunity protections, please visit www.agilent.com/en/accessibility.

Travel Required: No

Shift: Day

Duration: No End Date

Job Function: R&D