The Jie Yang Lab at the Department of Biochemistry and Molecular Genetics at University of Virginia School of Medicine is seeking a highly motivated postdoctoral scholar for structural and functional studies of macromolecular complexes using single particle cryo-electron microscopy (cryo-EM). The Yang Lab is dedicated to dissecting the molecular mechanisms of cellular stress response, specifically focusing on mitochondrial stress, endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and integrated stress response (ISR). We employ an interdisciplinary approach, integrating structural biology (Cryo-EM), biochemistry (protein reconstitution), and cell biology (fluorescent imaging). Our goal is to modulate those stress response pathways in physiological and pathological conditions based on our mechanistic insights, potentially leading to the development of novel therapeutics for related human diseases, including neurodegeneration, metabolic disorders, and cancer. More information about the Yang Lab can be found through https://jieyang-lab.com .
Postdoctoral employment is temporary and is normally limited to an individual who has been awarded a Ph.D. or equivalent doctorate within the previous five years1 and who will be involved in full-time research or scholarship at the University. Employment as a Postdoctoral Research Associate is viewed as training and is preparatory for a full-time academic or research career, is supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship during the training period.
The successful candidate will:
Full-time research or scholarship at the University.
Preparatory for a full-time academic or research career
Supervised by a senior scholar, and allows the appointee to publish the results of his/her research or scholarship
In addition to the above job responsibilities, other duties may be assigned.
Accurately document findings and coordinate with PI on future experiments
Present findings during lab meetings and possibly a conference
Assist Undergraduate, Graduate Students and Lab Staff when needed
MINIMUM REQUIREMENTS:
PhD degree in Structural Biology, Biochemistry, Molecular Biology, or a related Biomedical Science discipline is required.
Prior experience with cryo-EM, X-ray crystallography, protein expression and purification are preferred.
PHYSICAL DEMANDS
This is primarily a sedentary job involving extensive use of desktop computers. The job does occasionally require traveling some distance to attend meetings, and programs.
Review of applications will occur immediately and will continue until the position is filled. Selected Post Docs must have their completed PhD by the start date. This is a 12-month appointment with the possibility of renewal in one-year increments, contingent upon satisfactory performance and the availability of funding.
To Apply:
Apply Here, and search for R0066010.
Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs' and search for R0066010.
Complete an application online with the following documents:
Cover letter summarizing your pass experience, research interests, and career goals.
CV/Resume.
At least 3 letters of recommendation.
Attach these documents all into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs'. The successful candidate will pass a criminal background check and an Education Verification. (FSAKA).
For questions regarding this position, please contact Dr. Jie Yang, Assistant Professor. For more information on the benefits available to postdoctoral associates at UVA, visit postdoc.virginia.edu and hr.virginia.edu/benefits.
For questions about the application process, please contact Michelle Johnson, Recruiter.
For more information about UVA and the Charlottesville community please see http://www.virginia.edu/life/charlottesville and https://embarkcva.com/.
The University of Virginia, including the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex, pregnancy, sexual orientation, veteran or military status, and family medical or genetic information.