At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.
At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.
Job Summary
We are seeking a Research Engineer in the Laboratory for Translational Engineering at Brigham and Women’s Hospital with a background in biomedical engineering, chemical engineering, material science, pharmaceutical sciences or closely related field. Our research group consists of chemists, biologists, engineers, pharmaceutical scientists, and physicians and focuses on developing clinically relevant solutions to a host of challenges such as infectious diseases, metabolic diseases, and cancer.
Qualifications
We are seeking a Research Engineer in the Laboratory for Translational Engineering at Brigham and Women’s Hospital with a background in biomedical engineering, chemical engineering, material science, pharmaceutical sciences or closely related field. Our research group consists of chemists, biologists, engineers, pharmaceutical scientists, and physicians and focuses on developing clinically relevant solutions to a host of challenges such as infectious diseases, metabolic diseases, and cancer.
This project focuses on the highly exciting and burgeoning area of RNA delivery. Our group has pioneered several approaches in delivery of biologics across the gastrointestinal mucosa including RNA delivery. The goal of the project is to design systems for mRNA delivery in the gastrointestinal tract. The project will involve novel material synthesis (polymers and lipids) for and formulation development of mRNA nanoparticles. Nanoparticles will be characterized for their physicochemical properties and in vitro transfection. Lead formulations will be interfaced with chemical and physical permeation enhancers and tested for uptake in the gastrointestinal tract. We encourage individuals who have prior experience with nanoparticle-based drug delivery systems to apply.
Job Requirements
The candidate should possess B.S. required. M.S. preferred or equivalent in biomedical engineering, chemical engineering, material science, pharmaceutical sciences or closely related field.
Experience
Experience in device engineering in a hospital, industry, or academic 1-2 years preferred and Experience in medical engineering 0-1 year preferred
The ideal candidate will have experience in at least 2 of the areas listed below.
Synthesis of polymers and/or lipids, and their physicochemical characterization using techniques such as NMR, GPCMammalian cell cultureGeneral biological characterization techniques such as flow cytometry, PCR, western blotting, microscopyFormulation development (such as nanoparticles and microparticles) and characterization techniques such as dynamic light scattering (DLS)/ scanning electron microscopy (SEM) etc.
Training to gain further skills will be available.
Candidate must have self-motivation and willingness to learn new tools and techniques; strong organizational, interpersonal, and communication skills; ability to work independently and as part of a team; comfort summarizing and reporting results to interdisciplinary researchers; commitment to exceeding standards and producing accurate, high quality work; meticulous attention to detail; practiced documentation skills; and ability to follow safety procedures and maintain a safe work environment.
Additional Job Details (if applicable)
Remote Type
Onsite
Work Location
65 Landsdowne Street
Scheduled Weekly Hours
40
Employee Type
Regular
Work Shift
Day (United States of America)
EEO Statement:
The Brigham and Women's Hospital, Inc. is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.