At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community. We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.
At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.
Job Summary
We are seeking a highly skilled and motivated Staff Scientist with significant experience in spatial transcriptomics to join our cutting-edge research team. The successful candidate will play a pivotal role in the design, execution, and analysis of experiments employing advanced spatial transcriptomics technologies, contributing to high-impact research in cancer biology and molecular profiling. The candidate will integrate clinical medicine and biology with the spatial transcriptomics data generated for these projects.Key Responsibilities:
1. Experimental Design and Execution:
o Develop and implement spatial transcriptomics workflows using platforms such as NanoString GeoMx, CosMx, Xenium, and similar cutting-edge technologies.
o Perform staining, hybridization, imaging, and Next-Gen sequencing to generate high-resolution spatial transcriptomics data.
2. Data Analysis and Interpretation:
o Process, analyze and visualize large-scale spatial transcriptomic datasets using bioinformatics tools and pipelines.
o Integrate spatial data with clinical datasets to extract meaningful biological insights.
3. Collaboration and Mentorship:
o Collaborate with multidisciplinary teams, including Physicians, bioinformaticians, and clinical researchers, to drive research objectives.
o Provide training and guidance to junior researchers and technicians in spatial transcriptomics methodologies.
4. Research and Innovation:
o Contribute to the development of novel spatial transcriptomic techniques and applications.
o Prepare scientific manuscripts, grant proposals, and presentations for internal and external collaborators.
Qualifications
Qualifications and Requirements:
MD/Ph.D with a strong research background in spatial transcriptomics or equivalent experience.Clinical medicine training to integrate clinical science with molecular technologiesProficiency in spatial transcriptomics platforms (e.g., NanoString GeoMx, CosMx, or 10x Genomics Xenium).Expertise in molecular biology techniques including RNA/DNA extraction, quantitative PCR, Next-Generation Sequencing, and Digital Pathology analysis.Excellent organizational, communication, and collaborative skills.Demonstrated ability to lead projects and work independently in a fast-paced research environment.Preferred Skills:
Familiarity with cancer biology and tumor microenvironment studiesExperience in grant writing and manuscript preparation
Additional Job Details (if applicable)
Remote Type
Onsite
Work Location
149 Thirteenth Street Building 149
Scheduled Weekly Hours
40
Employee Type
Regular
Work Shift
Day (United States of America)
EEO Statement:
The General Hospital Corporation is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.