Job Title: Biochemical Assay Development Scientist
Job Description

We are seeking a talented and motivated individual with expertise in enzymology and biochemical assay development to support small molecule drug discovery. The successful candidate should possess strong technical expertise, exceptional hands-on laboratory skills, and have excellent written and oral communication skills. You should enjoy working in a fast-paced, multi-functional team environment and stay current with the latest literature and technology developments in your field.

ResponsibilitiesContribute to the assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development, and troubleshooting in support of small molecule drug discovery.Develop and execute biochemical assays and convert them into high-throughput screening (HTS) format to enable HTS campaigns and meet project goals.Apply sophisticated biochemical and biophysical assay techniques to develop and perform potency, kinetic, and mechanistic assays for hit validation, compound-target engagement, and SAR study.Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature.Strong data analysis capabilities and able to communicate and present research results and provide scientific and technical support.Collaborate with internal cross-functional teams and external partners to enable project progression.Essential SkillsExperience in evaluating and implementing new technologies to enhance screen capabilities and assay performance for small molecules.A deep and broad understanding of the development, validation, and execution of a wide array of binding and functional activity-based assays such as TR-FRET and PCR.Excellent organizational, interpersonal, and communication skills, along with the ability to work in a flexible, team-oriented environment.Additional Skills & QualificationsPhD in pharmacology, biochemistry, molecular biology, or a related discipline preferred, or exceptional working experience with an MS.Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies.Proficiency in assay development to screen and characterize covalent inhibitors.Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers.Expertise in handling, analyzing, and visualizing assay data sets and proficient in software platforms such as GraphPad Prism.Drug discovery research experience in diverse target classes is a plus.Detail-oriented and analytical with excellent problem-solving skills.Work Environment

The position is based in South San Francisco, CA, USA. You will work in a dynamic and collaborative environment where teamwork and flexibility are essential. The role requires hands-on laboratory work and the use of advanced scientific equipment and software platforms.

Pay and Benefits

The pay range for this position is $40.00 - $45.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in South San Francisco,CA.

Application Deadline

This position is anticipated to close on Apr 30, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

Diversity, Equity & Inclusion

At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:

Hiring diverse talent Maintaining an inclusive environment through persistent self-reflection Building a culture of care, engagement, and recognition with clear outcomes Ensuring growth opportunities for our people

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.