Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
 

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
 

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

Physical and Emotional Wellness

​Financial Wellness

Support for Caregivers
 

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
 

The Importance of the Role

As a member of the Early Research Process Development – Analytical Development group this position will be responsible for the design and optimization of long-read DNA sequencing methods for evaluation of Adeno-Associated Virus (AAV). The individual must have hands-on experience in using next generation sequencing (NGS) platforms, data analysis, and method troubleshooting. The individual will collaborate with Early Research Process Development, Gene Therapy Research, and additional internal and external stakeholders to ensure the development and transfer of robust analytical methods.

The Opportunity to Make a Difference

The successful candidate with be responsible for the following:Design, optimization, and execution of NGS projects on the PacBio Vega sequencing platform including:DNA extraction, isolation, and purification from AAVDNA library preparation for long read sequencingPacBio sequencer operationData quality monitoringData analysis and validationIn-depth understanding of principles and methods for sequencing analysisIdentifying and implementing operational improvements and novel technologies to solve analytical problemsWork seamlessly with cross-functional stakeholdersParticipate in project related teams and other internal/external collaborationsEnsure that scientific and technical challenges are resolved in a timely mannerMaintain all appropriate laboratory records, author technical documents, protocols, and reportsPerform routine data analysis and visualization for use in presentations, publications, and internal reportsContribute to a safe, efficient, and effective environment with personal accountabilityPerform other related duties as required

More about You

PhD Degree in Bioinformatics, Biostatistics, Biotechnology, Biochemistry, or related field1-3+ years of related experience in method development and analysis in gene therapy and/or viral vector biology preferredExtensive hands-on experience with sequencing analysis tools and scripting/programming for bioinformatics (command line bioinformatics)Adaptable to the evolving field of bioinformaticsHands-on experience of NGS library preparationExperience working with liquid handling workstationsExperience with Capillary Electrophoresis is desirableDNA/RNA quality control experience, e.g. TapeStation or equivalent, is desirableAbility to develop and troubleshoot methods with minimal supervisionExcellent written and verbal communication skillsProven record of successfully planning experiments and executing projects in collaboration with internal or external stakeholdersProven ability to work independently and effectively handle multiple priorities is a mustAbility to maintain confidentiality of proprietary information expected

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
 

#LI-Onsite

#LI-TG1

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $95,200 - $119,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.