Ridgefield, CT, 06879, USA
22 days ago
Scientist III/ IV, Exploratory Biomarkers
**Description** We are seeking a driven, energetic, results-oriented Scientist III or IV to join the Biomarker Discovery group of the Immunology and Respiratory Research Therapeutic Area in Ridgefield CT. This individual will develop _in vitro_ TE/PD and disease biomarker assays to support the Immunology and Respiratory Department portfolio projects and use innovative technologies to discover biomarkers to advance our novel research programs. This position requires hands-on experience on TE/PD and disease biomarker assay development in drug discovery, primary animal/human cell culture systems, ligand-binding assays, attentional to experimental detail, teamwork as well as strong communication and organizational skills. Flow cytometry experience is preferred. **Duties & Responsibilities** + As a technology expert, develops and implement experimental approaches that contribute to the Biomarker Discovery group goals in an independent and efficient manner, with minimal supervision + Designs, executes and troubleshoots routine and innovative TE/PD (including direct and indirect TE) and disease biomarker assays using animal/human matrices, analyzes experimental data, interprets outcome of experiments and proposes appropriate follow-up experimental plans + Interacts regularly with colleagues in the Biomarker group and other organization functions to move new therapeutic concepts through their lifecycle + Keeps abreast with literature and extracts relevant information from published protocols + Present own work at internal and external meetings + Proposes and contributes to the incorporation of new technologies and/or assume departmental responsibility for technical aspects of portfolio projects + Trains junior scientists in all areas of laboratory operations, productively contributes in a matrix organization and shares ideas across the department + Co-authors peer-reviewed manuscripts + Adapts best strategies internally and externally, complies with applicable regulations, performing all work in a safe manner and maintains proper records in accordance with SOPs and policies **Requirements** + Strong hands-on experience with development of TE/PD and disease biomarker assays in Drug Development, including direct and indirect TE assays and receptor/target occupancy assays + Experience with immunoassays + Experience using a variety of standard laboratory techniques such as mammalian cell tissue culture, various ligand-binding assay formats (i.e ELISA), peripheral blood cell cell isolation and culture, DNA/RNA extraction, RT-qPCR, western blot. + Ability to learn new technology and concepts + Proficiency in Microsoft Office, experience with Flow cytometry data analysis tools (i.e FlowJo) and GraphPrism softwares + Good verbal and written communication skills. + Independent thinker, planner, and executor of technical activities. + Strong analytical skills to effectively present test data and other related findings. **Scientist III:** Master´s Degree with 3+ years experience in related scientific discipline or Bachelor´s Degree with 7+ years experience in related scientific discipline or equivalent experience in related field **Scientist IV:** + Master´s Degree with 6+ years experience in a related scientific discipline or Bachelor´s Degree with 10+ years experience in a related field or equivalent experience in a related field **Compensation:**  This position, Scientist II, offers a base salary typically between $75,000.00 and $147,000.00.  The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here. (https://www.boehringer-ingelheim.com/us/careers/benefits-rewards) **Desired Skills, Experience and Abilities** + Hands-on experience with flow cytometry + Experience with method validation in Drug Discovery + Experience with omics technologies (i.e. proteomics), in particular application to biomarker discovery + Experience with handling of various clinical specimens **Eligibility Requirements:** + Must be legally authorized to work in the United States without restriction. + Must be willing to take a drug test and post-offer physical (if required). + Must be 18 years of age or older. All qualified applicants will receive consideration for employment without regard to a person’s actual or perceived race, including natural hairstyles, hair texture and protective hairstyles; color; creed; religion; national origin; age; ancestry; citizenship status, marital status; gender, gender identity or expression; sexual orientation, mental, physical or intellectual disability, veteran status; pregnancy, childbirth or related medical condition; genetic information (including the refusal to submit to genetic testing) or any other class or characteristic protected by applicable law.
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