Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Arrowhead is seeking a highly motivated scientists to join our discovery chemistry team in San Diego, CA. The successful candidate will possess a strong background in synthetic chemistry and experience in property/structure-based molecular design. As part of a platform team in discovery chemistry, this individual will drive chemistry strategies and conduct structure-activity relationships to advance the delivery platform of siRNA modality. 

This is a laboratory-based position.

Responsibilities

Design, synthesize, and characterize novel targeting moieties with siRNA constructs and siRNA-protein/peptide conjugates, with a focus on effective extrahepatic delivery strategy Stay updated with the latest advancements, including research papers and intellectual property literature in siRNA chemistry, conjugation strategies, and drug delivery systems to drive innovation and enhance project outcomes Work productively and safely in the laboratory and maintain good practice writing experimental reports in an electronic lab notebook Work closely with the biology therapeutic area (TA) group, design, and co-lead projects to advance our next-generation platform efforts through an improved understanding of mechanism and structure towards enhanced potency, safety, new target-ligand pairs, or other novel approaches Actively support our efforts towards the discovery of lead drug candidates and collaborate with our CMC department to transition novel modalities into development Track progress against project timelines, generate regular status updates, and communicate progress and issues to management

Requirements:

Ph.D. in synthetic organic chemistry, medicinal chemistry, or related discipline with 0-5 years post-degree experience in an industrial or academic setting Strong laboratory skills and experience with analytical instrumentation, such as HPLC, LC-MS, UV-Vis spectrometry, etc., Ability to work within cross-functional teams and work as a team player; possess a collaborative mindset with excellent verbal and written communication skills, excellent presentation skills, and attention to detail Ability to recognize impactful areas of research and organize both individual and team efforts to investigate using a broad range of approaches

Preferred: 

Experience in peptide discovery, ADCs (Antibody-drug conjugates) or PDC (peptide-drug conjugates)

 

California pay range $110,000—$150,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

California Applicant Privacy Policy