We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR-T or TCR T cells) from both early discovery programs as well as late-stage development programs' nonclinical studies that support regulatory submissions. We hope you are excited to be in a hands-on laboratory role in a fast-paced environment.

As a Senior Associate Scientist, a typical day might include:

Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications

Characterizing genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)

Developing and performing immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics

Designing experiments independently and contributing to the project direction

Maintaining an electronic lab notebook and documenting experiment results

Reviewing and presenting research data to the functional team

This role might be for you if you:

Have a can-do attitude, are curious, and excel in creative problem solving

Can multi-task and manage time well  

Can quickly adapt to new research areas and implement new techniques independently

Are scientifically rigorous, highly organized, and a self-starter with excellent attention to detail

Have strong verbal and written communication skills

Are self-motivated and enthusiastic about working in an interdisciplinary, collaborative research environment

In order to be considered for this role, you must have at least a BS/MS in immunology, cell biology or related field and 3+ years of relevant experience. Must have experience working in a biotech/pharmaceutical industry. We need someone with a strong understanding of immunology and cancer biology. Must have extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes. Experience working on in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA and cytotoxicity assays is required. Gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation a plus. Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA-Seq also advantageous.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions.  For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process.  Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)