About the Department As part of the establishment of our R&D Hub in greater Boston, Novo Nordisk is growing its efforts within chemical biology. A cornerstone of this is an expansion of our capabilities in measuring molecular interactions to support the validation of drug targets and advance drug research programs that address unmet needs within a broad range of serious chronic diseases. Building on our success in delivering to patients’ treatments for diabetes, obesity, and other chronic and rare diseases, we are rapidly growing our activities in our relentless pursuit of the next generation of novel therapies and exploration of new targets across a range of new modalities.  In growing our presence in the greater Boston area via our R&D Hub, we seek to bring together the 100-year heritage and experience of Novo Nordisk with the unparalleled innovation eco-system found in Boston. You will join and help build a vibrant and science-focused team of researchers, where innovation is at the core. Chemical Biology is part of Global Research Technologies, a key part of our R&ED organization which thrives on exploring new drug modalities, innovating screening and characterisation approaches, and enhancing delivery technologies to support projects across all therapeutic areas. We are an interdisciplinary team comprised of chemists, protein engineers, biologists, and assay experts, and we are currently expanding our capabilities in measuring molecular interactions of various biologics formats. We are based in the newly established lab facilities in Lexington and co-located with target discovery and early drug research groups. As part of a team of leading scientists and innovators, you will bring your own ideas and collaborate with others to develop the next generation of medicines. It’s ground-breaking work with the promise of improving the lives of millions of people with chronic diseases. If you want to make a difference, join us in pioneering research that can achieve a global impact. The Position In your role as a Senior Associate Scientist, you will be responsible for supporting design, development, validation and/or implementation of binding and biochemical assays to support target validation and drug discovery projects. You will work with diverse modalities, which may include proteins, peptides, small molecules, oligonucleotides, and/or their conjugates. You will contribute to maturing and advancing scientific ideas into projects within different therapeutic areas through experimental design and execution, ensuring data integrity and reproducibility, and communicating results to diverse project teams. In your daily work, you will collaborate closely with scientists within the Chemical Biology team, other teams across our growing US R&D Hub, and global project teams. The working environment in Global Research Technologies is dynamic and innovative and involves interactions with colleagues from research sites in Denmark, UK, and China, with an excellent opportunity to establish a strong global scientific network. Relationships Reports to of the head of Chemical Biology. Internal relationships include project teams and research colleagues in the greater Boston area and at global research sites elsewhere in the US, Denmark, China, and the UK. Communicates data externally when required. Individual Contributor: does not manage other employees or contingent workers. Essential Functions + Advances research projects by applying broad knowledge of molecular interactions. + Proposes, designs, develops, validates, and implements binding and biochemical assay technologies. + Provides subject matter expertise in protein binding kinetics and other techniques used for profiling the interaction of proteins with a variety of molecular formats. + Evaluates novel assay techniques and drives modification and adaptation of experimental protocols to enable the establishment of binding and biochemical assays as screening tools to advance programs from hit-to-lead. + Develops experimental protocols that meet or exceed industry-leading standards and ensures sharing of best practices with counterparts throughout the global R&D organization. + Analyzes complex data with high degree of sophistication, connecting disparate datasets to reach conclusions and set direction on experiments. Responsible for drafting study protocols, reports, and research proposals. + Effectively communicates experimental results to cross-functional project teams. May represent the organization at external conferences and by contributing to publication of scientific papers and patents. Participates in external collaborations as a contributor or subject matter expert as needed. + Studies scientific literature to support research projects and provide recommendations to research agenda. Expands the capabilities of Chemical Biology through the evaluation of new and emerging binding and biochemical assay methods and technologies. + Leads cross-functional experimental teams to achieve project goals, mentor junior staff, and provide training. + Influences the research pipeline by contributing recommendations to project teams. + Maintains and troubleshoots relevant lab instruments; provides hand-on instructions and training for new and less experienced team members. + Contributes to effective management of consumables, sample and reagent inventories, and other shared resources. Qualifications + A Bachelor's degree with 10 years or a Master's degree with 6 years, or a PhD with 0 years of relevant technical experience is required. A degree within biological, biochemical, or pharmacological sciences is preferred. Relevant required experience includes: + Significant first-hand experience with SPR and BLI, including an expert-level understanding of the underlying concepts, a demonstrated ability to design and optimize protocols to best enable measurement of a given molecular interaction, and mastery of the associated wet-lab techniques that allow for the efficient operation of relevant instruments and troubleshooting of experiments. + Demonstrates excellent verbal and written communication skills Preferred experience includes: + Experience with immunoassay-based techniques for assessing binding such as ELISA, AlphaScreen, AlphaLISA, or similar. + Experience measuring biomolecular interactions through the use of fluorescence-based or similar techniques such as FRET, BRET, or FP. + Experience with enzyme inhibition assays. + Experience with NMR-based techniques for measuring protein-protein, protein-peptide, or protein-small molecule interactions. + Experience with radioligand displacement and similar techniques for measuring drug target interactions. + Experience with basic techniques for measuring permeability such as PAMPA or Caco-2. + Experience with advanced techniques for measuring permeability such as Nano-Click or CAPA assays. We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing. Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations. If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.