Site: The Brigham and Women's Hospital, Inc.

 

At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech experts, to dedicated researchers and systems analysts. As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community.  We place great value on being a diverse, equitable and inclusive organization as we aim to reflect the diversity of the patients we serve.

At Mass General Brigham, we believe a diverse set of backgrounds and lived experiences makes us stronger by challenging our assumptions with new perspectives that can drive revolutionary discoveries in medical innovations in research and patient care. Therefore, we invite and welcome applicants from traditionally underrepresented groups in healthcare — people of color, people with disabilities, LGBTQ community, and/or gender expansive, first and second-generation immigrants, veterans, and people from different socioeconomic backgrounds – to apply.

 

New budgeted research role

 

Job Summary

Summary
Carries out a broad range of technically advanced research activities and procedures; evaluates conclusions and has considerable latitude to modify or devise methods and techniques as necessary to achieve desired results; typically supervises technical and sometimes administrative elements of the research unit. Helps onboard new staff and train them in the lab.

Essential Functions
-Develops or provides input into modifications of existing assay techniques, experimental protocols, or new procedures.
-Synthesizes and interprets results.
-Prepares written and/or verbal status reports.
-Performs statistical analysis and makes recommendations.
-Independently performs non-routine, highly specialized experimental procedures.
-Composes and may present sections of research reports and manuscripts.

Research Support – 70%
1. Collaborate closely with researchers to generate high-quality data for publications, grant proposals, and presentations.
2. Perform advanced mammalian cell culture techniques, including routine maintenance, transfection, and differentiation of various cell lines.
3. Independently execute molecular biology techniques, including but not limited to western blotting, qRT-PCR, cloning, and CRISPR/Cas9-based editing.
4. Assist in advanced microscopy imaging, including confocal and fluorescence microscopy, and take ownership of image acquisition, processing, and quantitativeanalysis.
5. Learn, master, and implement surgical techniques commonly used in preclinical models.
6. Optimize and troubleshoot immunofluorescence, immunohistochemistry, and in situ hybridization protocols.
7.Mentor and train new lab members and junior staff in specialized techniques such as mouse handling, genotyping, and experimental design.
Cell Culture – 20%
8. Differentiate, expand, and maintain multiple iPSC lines, ensuring cell quality and reproducibility across experiments.
9. Prepare and maintain viral vectors (e.g., lentivirus, AAV) for in vitro and in vivo applications, adhering to biosafety protocols.
10. Develop and maintain primary cultures from animal tissue, including neurons and glial cells.
Lab Upkeep – 10%
11. Maintain a clean and well-organized work environment, ensuring proper storage of reagents, cells, and samples.
12. Manage laboratory inventories, including ordering reagents and maintaining stock levels of commonly used consumables.
13. Calibrate and perform routine maintenance on critical lab equipment, such as microscopes, centrifuges, and PCR machines.
14. Assist in ensuring compliance with institutional biosafety, animal care, and chemical safety regulations.
15. Help maintain accurate lab documentation, including protocols, experimental records, and safety data sheets.

 

Qualifications

Education
MSc preferred, bachelor’s degree in biology or related major required. 3-5 years of relevant laboratory experience outside coursework required.
1. Demonstrated experience with mammalian tissue culture and aseptic technique.
2. Experience with rodent handling, husbandry, and animal experiments.
3. Must have demonstrated experience in molecular techniques, particularly cloning and transfection.
4. Ability to design, execute, and troubleshoot protocols and experiments for various projects in the lab.
5. Must be able to maintain detailed and accurate laboratory notebooks documenting experimental procedures, results, and observations.
6. Compile, analyze, and present data in a timely fashion.

Knowledge, Skills and Abilities
- Excellent communication skills.
- Good interpersonal skills and the ability to oversee the work of others.
- Ability to work independently.
- Ability to identify problems and develop solutions.
- Ability to prioritize tasks and set deadlines.
- Strong database management and overall computer skills.
- Functions with speed, precision and an understanding of theory behind tests and procedures.

 

Additional Job Details (if applicable)

 

Remote Type

Onsite

 

Work Location

60 Fenwood Road

 

Scheduled Weekly Hours

40

 

Employee Type

Regular

 

Work Shift

Day (United States of America)

 

EEO Statement:

The Brigham and Women's Hospital, Inc. is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

 

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.