Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Key Accountabilities/Core Job Responsibilities: 

Provide clinical leadership for registrational development programs in MPS II  Collaborate with translational sciences, clinical pharmacology, drug safety, biometrics, and other technical experts on the overall development program  Oversee the development of study protocols and clinical study reports, study medical monitoring, safety reporting, and other clinical-regulatory documents  Oversee clinical science aspects of design, execution, interpretation and reporting of efficacy and safety in late-stage clinical trials  Collaborate with academic scientists, clinical experts, and study investigators Represent and advocate for the project in internal and external venues  Act as a champion for high standards of compliance, ethics and safety, and putting patients first  Contribute scientific knowledge and leadership to the clinical science function Manage clinical science team members, leading direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.

Qualifications/Skills: 

MD or MD-PhD, with formal training in the areas of pediatrics, genetics, rare disease and/or neurology preferred 12+ years of relevant clinicalexperience with 6+ years in industry preferably in neurological rare disease, including experience leading cross-functional development teams and/or people management experience Demonstrated excellence and experience in late-stage clinical development in neurological indications, including the design, execution, and reporting of pivotal trials and NDA/BLA/MAA filing experience Ability to communicate effectively with clinical, biomarker, biostatistical, and pre-clinical scientists, including peer to peer interactions with academic scientific experts Track record of excellence in people management Demonstrated success in engaging regulatory approval agencies at end of Phase 2, NDA/BLA submission, and drug approval milestones Post-marketing clinical development, medical affairs, or drug safety experience is a plus This position may require travel up to 25% of the time in the future

Salary Range: $313,000.00 to $360,000.00 .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. 

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.