Description

Job Title:

Senior Scientist, PKPD

Location:

San Diego, CA / Hybrid / Remote

Position type:

FLSA:

Full time

Exempt

Department:

Finance ID:

Development Sciences

8100-2025-5

Profoundly Improve People’s Lives by Revolutionizing the Delivery of RNA Therapeutics

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and X.

The Opportunity

We seek an experienced drug developer and scientist to join the Development Sciences team at Avidity Biosciences in La Jolla, CA. This position will expand the PKPD and quantitative pharmacology efforts across all phases of development, from research through approval.  A highly visible role, with the opportunity to define and implement quantitative modeling and simulation for a new class of Antibody Oligonucleotide (AOC) therapeutics. In addition, the ideal candidate will work with the clinical teams as a clinical pharmacologist. Proven experience utilizing M&S approaches to solve drug development problems, working on project teams, and the ability to clearly communicate this work is required.

What You Will Contribute

Interpret preclinical pharmacokinetic and pharmacodynamic data to inform the design of preclinical pharmacology and GLP toxicology studiesUtilize existing and novel PKPD modeling and simulation approaches to answer complex biological and pharmacological questions regarding the mechanism of action of the AOC platformIndependently conduct non-compartmental PK, exposure-response analyses, population PK and PK/PD, and other modeling and simulation activities as appropriate for the project.Accountable for timely execution and reporting of PKPD, pharmacometrics analyses and reports for assigned projects.With guidance, author dose justification, clinical and quantitative pharmacology content for protocols, CSRs, global regulatory submissions, including INDs, CTAs, IBs, BLAs, MAAs and pediatric plans. As necessary, collaborate with Clinical, Regulatory, Biometrics, Bioanalytical, DMPK, Toxicology and others in planning and execution of nonclinical and clinical studies.As required, manage modeling and clinical pharmacology CROs in planning and timely execution of program deliverables.Ensure GxP and SOP training tasks are completed in a timely manner.Assist junior scientists in the design and conduct of preclinical PKPD studies to support drug candidate nomination and early preclinical drug development activities in-house and at contract research organizations.

What We Seek

PhD degree in pharmaceutics, biochemistry, pharmacokinetics, pharmacology, biomedical engineering, or related disciplineMinimum 5+ years’ experience in the biotech/pharmaceutical industry in the area of preclinical drug discovery and/or developmentExperience in the conduct, analysis, and interpretation of in vivo preclinical pharmacokinetic and PKPD studiesExperience with large molecule (monoclonal antibody and/or ADCs) and/or oligonucleotide therapeutic modalitiesExperience with characterization of ADME properties of drug candidates Industrial project team experience as either a representative or a key contributorStrong documentation and organizational skills

What We Will Provide To You

The base salary range for this role is $152,000 - $168,000. The final compensation will be commensurate with relevant experience, skillset, internal equity, and market factors. Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, RSUs, and a 401(k) with an employer match. In addition, the comprehensive wellness program includes medical, dental, vision, and LTD coverage and four weeks of time off.A commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

 

Avidity Biosciences

10578 Science Center Dr. Suite 125

San Diego, CA

92121

O: 858-401-7900

F: 858-401-7901

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