**Description** Boehringer Ingelheim is seeking a highly motivated Senior Scientist – Preclinical PK/PD Modeler to join the Biotherapeutics Discovery department locally at our US research facility in Ridgefield, CT. As a member of the NBE-PK group, the successful Senior Scientist will design and implement mechanistic PK/PD and quantitative systems pharmacology models in support of Boehringer Ingelheim’s highly innovative pre-clinical New Biological Entity (NBE) R&D portfolio. Will represent the PK/PD modeling discipline on multi-disciplinary drug discovery project teams and integrate PK/PD and target engagement considerations into team strategy and decision making. Will collaborate with key stakeholders in Discovery Research and clinical development in support of the overall translational research strategy for projects as well as enhance capabilities of the modeling group by implementing novel approaches and technologies. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development, and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, career development and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees. **Duties & Responsibilities** + Independently develops pre-clinical PK/PD and quantitative systems pharmacology models that enhance decision making for NBE target and candidate selections and inform translational research strategies for NBEs + Uses modeling and simulation to predict human efficacious dose/dose regimen, and influences selection of first-in-human starting dose + Designs quantitative pharmacology and pharmacokinetic studies, analyzes and interprets data, and clearly communicates results to teams and management + Leverages literature data or proposes new experiments to validate models or test model-generated hypotheses + Develops new methodologies, protocols or procedures that contribute to core group/research goals and reflect expert knowledge + PK/PD modeling representative on multiple cross-functional project teams + Effectively collaborates with scientists within and outside functional area (e.g. therapeutic area biologists, protein engineering scientists, clinical pharmacologists) + Prepares clear technical reports, publications, and oral presentations + Develops broad knowledge in field of expertise and enhances internal capabilities of group + Presents work at internal/external scientific meetings and publishes work in scientific journals **Requirements** + Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Quantitative fields such as applied mathematics, biomedical and chemical engineering or related discipline with proven track record of applying biomedical modeling and simulation approaches in academia or industry + Theoretical and practical knowledge of pharmacokinetics, PK/PD and quantitative systems pharmacology modeling + Experience using one or more commercially available modeling and simulation platforms (e.g. Phoenix/WinNonlin, NONMEM, MATLAB, SimBiology, etc.) + Experience in mechanism-based PK/PD modeling of therapeutic proteins is highly desired + Ability to build effective working relationships and influence others both inside and outside department inclusive of a virtual work environment + Strong aptitude for sharing expertise with cross-functional and global teams + Ability to communicate effectively both orally and in writing in an interdisciplinary environment + Committed to professional development of self and others **Desired Experience, Skills and Abilities:** + Proficiency with a scriptable modeling and simulation language (e.g. R, MatLab, Julia) + Experience with biomedical modeling techniques beyond ODEs, e.g. PDEs, spatial-temporal modeling, Agent-based modeling + Proficiency with PBPK (whole-body and minimal) modeling applied to biologics research and development + Experience with computational tools used for validation and verification of mechanism-based models (e.g. parameter estimation, sensitivity analysis, virtual population/patient simulations) **Eligibility Requirements** + Must be legally authorized to work in the United States without restriction. + Must be willing to take a drug test and post-offer physical (if required) + Must be 18 years of age or older **Compensation Data** This position offers a base salary typically between $140,000 and $222,000.  The position may be eligible for a role specific variable or performance-based bonus and or other compensation elements.  For an overview of our benefits please click here. (https://www.boehringer-ingelheim.com/us/careers/benefits-rewards) All qualified applicants will receive consideration for employment without regard to a person’s actual or perceived race, including natural hairstyles, hair texture and protective hairstyles; color; creed; religion; national origin; age; ancestry; citizenship status, marital status; gender, gender identity or expression; sexual orientation, mental, physical or intellectual disability, veteran status; pregnancy, childbirth or related medical condition; genetic information (including the refusal to submit to genetic testing) or any other class or characteristic protected by applicable law.