**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us . The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. **Position Summary:** We are seeking a talented individual with oncology translational and/or discovery research experience to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, engaged, and creative scientist that can thrive in a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Proof of Concept clinical trials. This individual will focus on exploring patient stratification hypothesis, identifying rational drug combinations, exploring mechanisms of action and mechanisms of resistance, and developing pharmacodynamic and target engagement assays. **Position Responsibilities:** In the role as a Senior Scientist within Oncology Translational Research, the ideal candidate will: + Develop biomarker, pharmacodynamic and target engagement assays. + Use current and new techniques to address drug mechanism of action and sensitivity/resistance studies. + Leverage familiarity with antibody drug conjugate (ADC) or/and knowledge in DNA damage repair signaling pathways to obtain decision driving data and contribute to building of the translational strategy and plan for clinical implementation. + Interact with project teams and contract laboratories for the design and oversight of molecular, cellular and/or in vivo studies. + May be responsible for co-authoring non-clinical pharmacology study reports and scientific publications. + Expected to understand departmental goals and development processes. + Execute experiments independently, troubleshoot as needed, interpret and discuss data. + Display excellent communication and interpersonal skills. **Experience =** **Basic Qualifications:** + Bachelor's Degree + 7+ years of academic and / or industry experience OR + Master's Degree + 5+ years of academic and / or industry experience Or + Ph.D. or equivalent advanced degree in the Life Sciences + 2+ of academic and / or industry experience **Preferred Qualifications:** + Ph.D. with postdoctoral experience and/or 1-3 years of industry experience. Strong knowledge of Antibody-Drug Conjugate (ADC) platforms and/or DNA damage repair signaling pathways is highly preferred. Experience performing laboratory work, including handling cell cultures, and performing analysis of protein and DNA/RNA samples using a variety of methodologies including but not limited to: flow cytometry, MSD/ELISA, Luminex, RNAi, CRISPR, qPCR and primary culture and functional assays. + Ability to conduct experimental work independently, with accurate, detailed record-keeping. + Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work. + Ability to summarize and interpret scientific data in a clear, concise, and accurate manner. + Excellent oral and written communication skills. Ability to communicate well with peers and supervisors. + Strong problem-solving skills and understanding of relevant scientific principles. + Ability to be flexible in case of changing priorities. \#LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. **Uniquely Interesting Work, Life-changing Careers** With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. **On-site Protocol** BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/ Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. **Company:** Bristol-Myers Squibb **Req Number:** R1591790 **Updated:** 2025-05-11 01:30:49.027 UTC **Location:** Cambridge Crossing-MA Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.