This Opportunity:
We are seeking a highly motivated Senior Scientist with a track record of scientific excellence in in-vivo pharmacology to join our Oncology Small Molecules team in Waltham MA USA. As a Senior Scientist, you will be leading from the bench delivering in vivo pharmacology data to support our oncology small molecules' portfolio, with a focus on drugs targeting Breast, Ovarian, Lung and Colorectal cancers.
Key Responsibilities:
Use in vivo technical skills to support our oncology platform by:
Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous and orthotopic xenograft models and Patient Derived Xenograft models.
Designing and performing in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support early and late-stage drug discovery programs.
Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches.
Work collaboratively across fields to develop and implement aggressive work plans and timelines.
Show strength and flexibility in working with various programs and databases to collect all study data for broad access by project teams and partners.
Essential requirements:
BS/MS with 5+ years’ experience or PHD with 2+ years of experience in biology, pharmacology, or related field with a minimum of 2 years “hands-on” in vivo experience.
Practical in vivo experience and experimental skills in the use of mouse models.
Ability to work both independently as well as within project teams and across subject areas such as DMPK and translational medicine.
Exceptional communication, listening and organizational skills. Ability to analysis, organize and present data in an appropriate manner for a given audience.
Understanding of statistical methods and quality control of data.
Familiarity with GraphPad Prism, Microsoft Office, and in vivo data capturing systems such as Study Log.
Additional experience desired:
Industry experience leading strategic and technical in vivo delivery to advance drug discovery/development.
Experience measuring biomarkers in blood and tissue samples using techniques such as IHC, Western blot, ELISA and MSD-based platforms.
Experience using small animal imaging modalities such as IVIS to monitor bioluminescence.
Why AstraZeneca?
At AstraZeneca, we embrace opportunities for change to drive meaningful advancements. Our mission is clear: to deliver life-changing medicines and redefine possibilities in biopharma. By combining diverse perspectives, pioneering science, and bold ideas, we are transforming patient outcomes worldwide.
Where You Can Learn More
· Follow AstraZeneca on LinkedIn
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Benefits
We offer a competitive Total Reward program, including:
· Competitive base salary, annual bonus, and long-term incentives
· Generous paid time off program
· Comprehensive benefits package
Diversity and Inclusion at AstraZeneca
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive team that represents a diverse group of backgrounds and perspectives, knowing that inclusion drives better outcomes.We welcome all qualified candidates and align with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations during the application or interview process, as well as for essential job functions.
Date Posted
22-Jan-2025Closing Date
20-Feb-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.