**Join Amgen’s Mission of Serving Patients** At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist **What you will do** Let’s do this. Let’s change the world. Are you passionate about advancing scientific discovery in the field of cardiometabolic diseases? Do you thrive in a dynamic, hands-on laboratory environment? Join our innovative team in San Francisco as a **Senior Scientist** and play a pivotal role in driving our pre-clinical pipeline forward! At the forefront of cutting-edge research, our Cardiometabolic Therapeutic Area team is dedicated to understanding the complexities of disease biology and discovering novel therapeutics. In this vital role you will collaborate with a team of world-class scientists, leveraging state-of-the-art technologies to make a real impact on patients' lives. + Design and perform laboratory-based assays to deepen our understanding of cardiometabolic disease biology + Screen and evaluate potential therapeutics to advance the pre-clinical pipeline + Utilize your expertise to generate CRISPR-edited stable cell lines and explore disease mechanisms through single-cell transcriptomics and other omics data sets + Apply your knowledge of rodent handling and dosing techniques to support in vivo studies **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications. **Basic Qualifications:** + Doctorate Degree (PhD) **Or** + Master’s Degree with 3+ years of experience **Or** + Bachelor’s Degree with 5+ years of experience. **Preferred Qualifications:** + Proficiency in designing and executing FACS panels and conducting routine flow-based expression analysis. + Extensive experience in high-throughput cell-based assays, including live cell imaging and image processing, qPCR, ddPCR, Western Blot, and ELISA + Hands-on expertise with CRISPR technology for generating stable cell lines + Experience with single-cell transcriptomics or other omics data for disease pathology and novel target identification (preferred) + Basic rodent handling and dosing experience, including SQ, IP, IV dosing, and end-point necropsy + Prior industry experience is a plus **What you can expect from us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models, including remote and hybrid work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. **Application deadline** Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.