Job Description

A. Position Objective

We are looking for a highly motivated individual with expertise in drug design, synthesis, as well as small molecule drug development and evaluation. The overall role is to work on small molecule drug evaluation and validation, and work closely with biologists in the team for assay development and experimental design.

B. Duties and ResponsibilitiesUtilize expertise in drug synthesis and small molecule drug development to lead the initial assessment and screening of small molecule projects, identifying those with the potential for further evaluation and development.Conduct in-depth analysis of molecule structures, synthetic routes, and compound properties, integrating molecular and functional group assessments to ensure comprehensive and reliable drug evaluation, and monitor project progress for developmental efficiency.Provide critical insights to guide decision-making on potential collaborations, leveraging expertise in small molecule projects.Drive and oversee the execution of small molecule project milestones, ensuring coordinated data verification, quality control, and strategic guidance to support innovative collaborations with partners and advance project goals.Offer strategic recommendations for optimizing small molecule compound structures, physicochemical properties, and synthesis routes, contributing to the enhancement of project efficiency and success.Collaborate closely with the biology team to develop assays and experimental designs, facilitating an integrated approach to small molecule drug evaluation.Develop and expand capabilities in the evaluation and collaboration of RNA and peptide-based drug projects, contributing to the exploration of innovative and potential high-impact projects.

C. Key Requirement

Education and Background:

Ph.D. in a chemistry-related field with more than 5-8 years of industry experience.Approximately 3-5 years of experience in drug design and synthesis.Experience as a project leader in small molecule drug development, with the successful completion of at least one project (from hit to the filing of an IND)Strong understanding of RNA and peptide-based drug is preferred.Strong understanding of evaluation assays and toxicology experiments.Experience in evaluating patent coverage, and experience in writing composition of matter patent is preferred.Experience in AI-driven small molecule drug design and modification is a plus.Experience in leading at least one full-cycle project from Discovery to IND filing is preferred.

Communication and Presentation Skills:

Excellent written and verbal communication skills in Chinese and English.Strong presentation skills.

Collaboration and Analytical Skills:

Strong interpersonal skills and ability to work effectively with cross-functional teams.Critical thinking, analytical mindset with attention to detail in gathering and interpreting data accurately.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

Job Posting End Date:

04/8/2025

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Requisition ID:R320590