This is what you will do:

This position will play a key role in Alexion’s Viral Vector Product Development, Vector Production team, interacting with internal teams within the Genomic Medicine and Product Development Clinical Supply groups. The Senior Scientist will be responsible for supporting both upstream and downstream AAV manufacturing.

You will be responsible for:

Leading AAV upstream manufacturing including but not limited to cell culture, transfection, and harvest for mid-large scale bioreactorsEstablishing rapid and robust testing methods for optimization of the upstream processesDirecting downstream AAV purification via chromatography-based methodsAssessing upstream & downstream processes for improvement in yields/recoveries as well as ways to boost overall qualityChampioning creative process improvement initiativesDeveloping small-scale high-throughput processes to generate high quality material for early screening and development workAdvanceing new/innovative process adaptations to facilitate production of novel productsLeading technical projects and routinely managing the work of others to facilitate technical milestone deliverables.Presenting data and findings to diverse groups both internally and externally facingProviding innovative and ambitious solutions to challengesSupporting the authoring of regulatory documents, technical protocols, reports, and peer-reviewed external journal articles; presenting scientific findings at scientific conferencesStaying up to date in current developments in the AAV manufacturing fieldMaintaining digital laboratory notebooks with proper documentation

You will need to have:

Qualifications / Training & Education

Bachelor’s degree in biology, or a relevant field with 3-4yrs experience or Master’s degree with 2-3yrs experienceStrong understanding of Good Laboratory Practices for bioprocessing, manufacturing & analytics

Knowledge & Experience

Strong track record of building successful relationships with supervisors, peers, suppliers, customers, partners and stakeholdersExcellent communication skills and ability to work well with multiple individuals.Ability to work on several projects simultaneously and to switch focus as neededAptitude in keeping accurate and organized records

Technical Competencies

Technical proficiency with laboratory automation and high throughput technologies: such as AKTA Avant, AKTA Pilot, AMBR250, TECAN, etc.Proficiency with large scale bioreactors (50L to 500L)Expertise in chromatography-based purificationRobust molecular/microbiology skillsExpertise in aseptic techniqueTrack record of prioritizing multiple, complex, high priority tasks and ensuring timely delivery to meet project needsA strong attention to detailWorking knowledge of Microsoft Office products, especially with Microsoft ExcelThe duties of this role are generally conducted in a lab environment.  As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

Proven track record and expertise with AAV process development and troubleshooting (upstream & downstream)Knowledge and the use of statistical analysis, multivariate data analysis and DOE.Demonstration of expertise in column chromatography for vector purification and filtration technologies.Proficiency with Unicorn software and writing methodsExperience with analytical assays related to AAVExperience with packing, cleaning, and testing chromatography columns

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.