Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Our Process Development team is seeking a student intern to support the synthesis and optimization of a key regulatory starting material. In this role, you will gain hands-on experience in chemical process development, contributing to improvements in the early synthesis steps and assisting with impurity characterization in later stages. This internship provides a unique opportunity to apply your knowledge of chemistry in a dynamic, research-driven environment while collaborating with experienced scientists to enhance process efficiency and product quality. If you are eager to develop practical skills in synthesis and analytical techniques, we encourage you to apply!

This is a 12 week Summer Internship Program paying $19.00/hr.   

Responsibilities

Conduct chemical reactions on scales ranging from 1 g to 100 g Isolate and purify target compounds using chromatography and recrystallization techniques Characterize organic compounds using analytical methods such as HPLC-MS and NMR, and collect additional data as needed (e.g., water content via Karl Fischer titration) Screen and evaluate various reaction conditions, systematically track and interpret data, and present findings to the team in weekly meetings Maintain a clean, accurate, and detailed laboratory notebook to document experiments and results

Requirements:

Currently enrolled student at an Accredited University or College and majoring in, Chemistry, Chemical Engineering, or related area of study Completion of at least one semester of organic chemistry and one semester of organic chemistry lab. Excellent verbal and written communication skills Strong problem-solving skills Eagerness to learn new techniques Ability to work in a lab setting for prolonged periods of time Ability to wear personal protective equipment as required Must be able to lift 15 pounds at a time Wisconsin pay range $9,120—$9,120 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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